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Glossary Penetration

ability of a substance to pass through skin or hair

Penetration, in the context of hair and scalp treatments, refers to the ability of a substance to pass through the outer layer of the skin or hair shaft to reach deeper layers. This is crucial for the effectiveness of topical treatments, such as minoxidil for hair growth, as it ensures that active ingredients can reach the hair follicles where they exert their effects.

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Research

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research Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles

316 citations , June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that using a standardized protocol with microspheres of approximately 1.5 micrometers enhances penetration into hair follicles, particularly when skin is treated with cyanoacrylate skin surface stripping.

research Penetration of drugs through skin, a complex rate-controlling membrane

211 citations , June 2012

This review discusses recent advances in skin penetration mechanisms, specifically focusing on the enhanced understanding of the follicular pathway and its implications for transdermal therapies, immune system targeting, and nanoparticle safety.

Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil

research Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil

128 citations , July 2009 in “International Journal of Pharmaceutics”

This study found that penetration enhancer-containing vesicles significantly improved minoxidil delivery to the skin compared to traditional liposomes and penetration enhancer-containing ethanolic solutions, with deformability linked to enhanced deposition.

research Penetration and storage of particles in human skin: Perspectives and safety aspects

122 citations , April 2011 in “European Journal of Pharmaceutics and Biopharmaceutics”

This review discusses the mechanisms and storage of particles in hair follicles and presents no new experimental results, highlighting the need for further research in their safe application in dermatology and cosmetics.

research Penetration of silver nanoparticles into porcine skinex vivousing fluorescence lifetime imaging microscopy, Raman microscopy, and surface-enhanced Raman scattering microscopy

90 citations , November 2014 in “Journal of Biomedical Optics”

In this study, silver nanoparticles were found to penetrate porcine skin to depths ranging from 11.1 μm to 15.6 μm, potentially surpassing the stratum corneum thickness.

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Community Join

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community So I earlier used to use the alchol variant but it lead to dryness in scalp and I switched to a non alchol variant that contains oleanolic acid , is it more or less the same , coz I heard alchol helps in better penetration so wondering if this would reduce my hair growth.

1 upvotes 3 years ago

The user switched from an alcohol-based Minoxidil to a non-alcohol variant with oleanolic acid due to scalp dryness. They are concerned if the non-alcohol variant will be less effective for hair growth.

community Is the “crunching” sound during microneedling my scalp actually the needles cutting through hair?

161 upvotes 5 months ago

The "crunching" sound during microneedling is likely the needles penetrating the scalp's outer layers, not cutting hair. Users suggest using a derma stamp instead of a roller to avoid potential hair damage.

community Nanoxidil Is Probably Better Than Minoxidil. Big Pharma Is Why You’ve Never Heard Of It.

5 months ago

Nanoxidil may be more effective than Minoxidil for hair loss due to better follicle penetration, but it lacks widespread recognition and research because it's owned by a small company and classified as a cosmetic. The pharmaceutical system favors Minoxidil due to its established market presence and profitability, leaving Nanoxidil largely unstudied and unknown.

community What’s a good carrier for GHK-Cu or AHK-Cu peptides to penetrate skin?

9 upvotes 4 months ago

Copper peptides for hair loss, discussing carriers for skin penetration and recommending a product from Amazon.

community Has Anyone Heard About Ethossomal Finasteride? 6x Finasteride Delivery in Hair Folicule?

36 upvotes 3 years ago

A user is considering switching from oral to topical finasteride to reduce systemic DHT impact and is exploring ethossomal finasteride for better skin penetration and potential hair regrowth. They found ethossomal finasteride in Brazil and are seeking opinions on its effectiveness compared to other topical delivery methods.

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