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GlossaryPenetration

ability of a substance to pass through skin or hair

Penetration, in the context of hair and scalp treatments, refers to the ability of a substance to pass through the outer layer of the skin or hair shaft to reach deeper layers. This is crucial for the effectiveness of topical treatments, such as minoxidil for hair growth, as it ensures that active ingredients can reach the hair follicles where they exert their effects.

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community RU58841 vehicle penetration (Study for minoxidil)

in Treatment 12 upvotes 1 year ago

The user mixes their own RU58841 solution and found that increasing the ethanol content improved absorption and reduced scalp itching. A study on minoxidil showed that penetration increased with higher ethanol concentrations, reaching maximum penetration at 90% ethanol.

community Castor oil without using penetration enhancer after microneedling?

in Question 9 upvotes 6 years ago

The conversation is about whether castor oil can be effectively used alone after microneedling without a penetration enhancer like DMSO or ethanol. The user believes microneedling-induced wounds might be enough for absorption.

community So I earlier used to use the alchol variant but it lead to dryness in scalp and I switched to a non alchol variant that contains oleanolic acid , is it more or less the same , coz I heard alchol helps in better penetration so wondering if this would reduce my hair growth.

in Minoxidil 1 upvotes 1 year ago

The user switched from an alcohol-based Minoxidil to a non-alcohol variant with oleanolic acid due to scalp dryness. They are concerned if the non-alcohol variant will be less effective for hair growth.

community Is there a way to boost/enhance the effects of minoxidil?

in Minoxidil 8 upvotes 4 years ago

Enhancing minoxidil effects can involve using penetration enhancers like DMSO, urea, or retinol, and methods like dermarolling and adding substances like biotin and L-carnitine tartrate. Some users suggest trying higher concentrations of minoxidil if lower percentages are ineffective.

community Has Anyone Heard About Ethossomal Finasteride? 6x Finasteride Delivery in Hair Folicule?

in Finasteride/Dutasteride 36 upvotes 1 year ago

A user is considering switching from oral to topical finasteride to reduce systemic DHT impact and is exploring ethossomal finasteride for better skin penetration and potential hair regrowth. They found ethossomal finasteride in Brazil and are seeking opinions on its effectiveness compared to other topical delivery methods.

community Pyrilutamide vs enzalutamide. Same thing?( Especially for biochemists, farmacologists)

in Research/Science 17 upvotes 2 years ago

Researching whether pyri and enza, which are stereoisomers of each other, share the same features related to CNS penetration/GABA Inhibition; safety and efficacy when used topically at 0.5-1%; and cost comparison between the two treatments.

community Self-Experiment - Topical Rapamycin or a-KB

in Treatment 4 upvotes 2 years ago

A user plans to create a DIY topical treatment for hair loss using Rapamycin, possibly combined with alpha-ketoglutaric acid (a-KG). They discuss the concentration and formulation process for Rapamycin, considering safety and skin penetration, and intend to apply it every other day to the scalp.

community I found the solution for the Minox dandruff problem

in Minoxidil 9 upvotes 3 years ago

A user found a solution for Minoxidil-induced dandruff by using a custom NRF 11.121 mixture from a local pharmacy, which includes ingredients like Isopropyl palmitate and Cremophor RH 40. This formulation prevents dryness and allows better penetration when using hair shaders.

community Does seborrheic dermatitis block absorption of topicals?

in Treatment 10 upvotes 1 year ago

User wonders if seborrheic dermatitis blocks absorption of topicals for hair loss. They use nizoral to improve the condition but it's not fully gone.

community Where have all the microneedle pens gone?

in Microneedling 15 upvotes 1 month ago

Microneedle pens for hair loss are harder to find on Amazon due to FDA regulations on needle length. Users suggest buying from AliExpress or Temu instead.

community "When comparing 5% minoxidil with 0.60 mm or 1.20 mm needle lengths, Faghihi et al. found that 0.60 mm needle lengths led to significant hair count and diameter increases versus 5% minoxidil, whereas 1.20 mm needle lengths only saw hair count increases versus 5% minoxidil"

in Research/Science 60 upvotes 5 months ago

Microneedling with 0.6 mm needles combined with 5% minoxidil is more effective for hair count and thickness than minoxidil alone or with 1.2 mm needles. Biweekly microneedling at 0.6 mm depth is recommended for better results in treating androgenetic alopecia.

community Using essential oils as well as minoxidil?

in Minoxidil 6 upvotes 6 years ago

The conversation is about using a blend of coconut oil, peppermint oil, and rosemary oil with minoxidil for hair loss, and whether it's safe to apply this blend after microneedling.

community Can use olive oil instead of PG (propylene glycol) or glycerin in topical finasteride preparation?

in Finasteride/Dutasteride 2 upvotes 3 months ago

A user asked if olive oil can replace propylene glycol or glycerin in topical finasteride preparation. Another user advised against it, suggesting MCT oil instead due to olive oil's potential to worsen dandruff and seborrheic dermatitis.

community Soundwaves & Electricity Grows Hair? | Peptide Delivery Model.

in Research/Science 2 upvotes 3 months ago

Iontophoresis and sonophoresis can enhance drug delivery into the scalp. Combining these methods may improve the effectiveness of topical treatments like dutasteride and certain peptides.

community This Cheapie Amazon Minoxidil Has Worked Wonders For Me

in Minoxidil 1 upvotes 5 months ago

A user switched from Kirkland minoxidil to a cheaper Amazon brand called Adellina, which includes Biotin, Ginseng extract, and Collagen, and saw significant hair growth within a week. They also transitioned from oral to topical finasteride after achieving their hair growth goals.

community Best device for microneedling?

in Microneedling 9 upvotes 6 months ago

The conversation is about someone seeking advice on the best microneedling device to use for hair loss, mentioning pens, stamps, and rollers as options.

community Propylene glycol vs ethyl alcohol(70% or 96%) for topical finasteride solution. Pros and cons?

in Finasteride/Dutasteride 4 upvotes 7 months ago

The conversation discusses the pros and cons of using propylene glycol versus ethyl alcohol in topical solutions for finasteride and minoxidil. It questions why propylene glycol is commonly used and whether ethyl alcohol might be a better option.

community Keratin microspheres - breakthrough

in Research/Science 13 upvotes 8 months ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community Micro needling 25 days progress. I’ve been on fin and min for 6 months but micro needling has done SO much more to actually restore my hairline

in Progress Pictures 569 upvotes 8 months ago

A user shared a 25-day progress picture showing significant hairline restoration attributed to microneedling, in addition to using minoxidil and finasteride for 6 months. Other users discussed needle length, frequency, and whether the effects of microneedling are permanent.

community 4 Month Progress - Fin/Min/Microneedle (32M)

in Progress Pictures 325 upvotes 1 year ago

A man shared his 4-month progress using finasteride, minoxidil, and microneedling for hair loss treatment. He experienced positive results without side effects, and plans to continue the regimen.

community Looking for treatment to increase efficacy of minoxidil

in Chat 7 upvotes 1 year ago

User seeks treatment to increase minoxidil efficacy. Suggestions include microneedling, oral minoxidil, and Tretinoin, with mixed experiences and side effects.

community All Drugs in Clinical Trials in 2023

in Research/Science 70 upvotes 1 year ago

12 companies having drugs or therapies in clinical trials during 2023, with various molecules and phases of trial; the probability that some may fail; and progress being made in the field.

community Homemade Topical Finasteride Formula?

in Treatment 7 upvotes 2 years ago

User wants to make homemade topical finasteride to minimize side effects and asks about using glycerin, stirring time, storage, and alternative solvents. Another user's comment is unclear.

community 126 Days of Fin/Min/Niz/Microneedling

in Progress Pictures 215 upvotes 2 years ago

User shared 126-day progress using Fin/Min/Niz/Microneedling for hair loss. Others discussed microneedling depth, results timeline, frontal coverage, and switching to Dutasteride.

community Who is using or has used Maxogen-X ?

in Product 6 upvotes 3 years ago

The conversation is about using Maxogen-X for hair loss, which contains Minoxidil, Finasteride, Azelaic Acid, ABN Complex, Retinoic Acid, Fluocinolone, and Caffeine. The user is seeking feedback on its effectiveness.

community Creating the Holy Grail Hair Loss Topical

1 upvotes 4 years ago

The conversation is about creating a natural hair loss topical using ingredients like cetirizine, Zinc Sulphate Heptahydrate, Safflower Extract, Ricinoleic Acid, and others. The user is seeking input and collaboration on this topical formula.

community whoa, my hair stopped falling out?

in Question 28 upvotes 6 years ago

A user reported that using 0.5 mg finasteride daily, biotin, Nizoral shampoo, and occasional castor oil scalp massages stopped their hair loss after six months. Another user expressed hope for similar results with castor oil.

community Red Light Therapy: Cheap Chinese LED caps are better than $3000 laser caps

in Research/Science 33 upvotes 3 weeks ago

Affordable 92-LED caps may be more effective for hair growth than expensive 270-laser caps due to higher power output and irradiance. The LED caps deliver more energy to the scalp, making them a cost-effective alternative for red light therapy.

community 20 year old male 4 month progress on 2.5min, 1mg fin, 1.5mm derma stamp.

in Is this regrowth? 192 upvotes 1 month ago

A 20-year-old male experienced significant hair regrowth and reduced shedding after four months of using 2.5mg oral minoxidil, 1mg oral finasteride, and weekly 1.5mm derma stamping. He reported no side effects from the treatments and noted increased hair growth in other areas of his body.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 4 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.