196 citations
,
March 2016 in “Nature Communications” In this study, researchers identified 18 genetic associations with scalp and facial hair traits in Latin Americans, including novel loci for hair greying and balding, with implications for understanding hair evolution.
15 citations
,
November 2015 in “Trends in biotechnology” This article discusses strategies for changing hair color by regulating target genes in hair follicles using advanced delivery systems, but it reports no new experimental findings.
193 citations
,
January 2015 in “International journal of trichology” This review examines hair cosmetics, including shampoos and conditioners, for their formulations and effects, but reports no new clinical findings; it emphasizes the importance of dermatologist knowledge in treating diverse hair conditions.
28 citations
,
March 2014 in “Biological reviews/Biological reviews of the Cambridge Philosophical Society” This study introduces the multiple papillary centres model, offering a new explanation for hair twisting by combining known hair morphology features with differential growth rates caused by dermal papillae.
55 citations
,
February 2014 in “Journal of Structural Biology” This study observed that human hair macrofibrils predominantly exhibit a double-twist architecture with varying inter-macrofibril angles, advancing insights into their structural organization and mechanical implications.
223 citations
,
January 2014 in “International Journal of Molecular Sciences” This article reviews the complex signaling pathways between epithelial and mesenchymal cells crucial for hair follicle morphogenesis, highlighting the Wnt pathway's role as a master regulator without reporting new experimental findings.
73 citations
,
October 2013 in “International Journal of Cosmetic Science” This review examines the chemical composition and potential health risks of hair straighteners, but it reports no new findings and emphasizes the importance of understanding hair fibre structure for safe use.
46 citations
,
June 2013 in “Journal of structural biology” This study suggests that the mechanical robustness of hair may be enhanced by the binding interactions of keratin-associated proteins, particularly KAP8.1, with intermediate filament proteins.
169 citations
,
June 2013 in “Medicine” This article reviews the structure and function of the skin and its importance for understanding skin diseases, without providing new clinical results.
47 citations
,
January 2013 in “International Journal of Cosmetic Science” This review explores genetic and lifestyle factors influencing hair diversity and reports no new findings, calling attention to the potential for future discoveries in genetic and epigenetic research.
55 citations
,
January 2013 in “International Journal of Cosmetic Science” In this study, researchers found that higher concentrations of internal lipids in African hair may influence its keratin structure, as observed through various analytical methods.
45 citations
,
January 2012 in “Experimental Dermatology” This study reveals that human hair follicles transition between active and dormant states stochastically, challenging the idea of a cyclical automaton controlling hair growth.
97 citations
,
March 2010 in “The American Journal of Human Genetics” A mutation in the KRT74 gene causes tightly curled hair.
44 citations
,
January 2010 in “International journal of trichology” This article discusses the complexity of selecting hair cleansing products and conditioners and reports no new scientific findings or results.
13 citations
,
January 2010 in “Advances in Biochemical Engineering / Biotechnology” This review covers various aspects of hair biology, pigmentation, and development, focusing on genetic and biochemical modulation of hair follicle components but reports no new findings.
234 citations
,
November 2009 in “American journal of human genetics” This study identified genetic variants in the Trichohyalin gene that account for approximately 6% of the variance in hair morphology among Australians of European descent.
9 citations
,
March 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that the maintenance and morphogenesis of skin appendages rely on both the dose and duration of ectodysplasin signaling.
95 citations
,
March 2009 in “Differentiation” Gene expression in wool follicles changes with growth cycles, offering insights into wool and human hair growth.
759 citations
,
February 2009 in “Current Biology” This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.
62 citations
,
December 2008 in “Journal of structural biology” This study found that in naturally curved human scalp hairs, distinct arrangements of cell types on either side of the hair fiber contribute to its curvature.
209 citations
,
September 2008 in “Dermatologic Therapy” This review discusses the role of androgens in hair follicle regulation and suggests that a better understanding could enhance treatments for conditions like hirsutism and alopecia, but does not present new findings.
98 citations
,
June 2008 in “Human mutation” This study found that a genetic variant in the EDAR gene leads to typical East Asian hair characteristics by increasing signaling output, as shown in transgenic mice experiments.
31 citations
,
May 2008 in “Drug Discovery Today: Disease Mechanisms” This review discusses the physiology of hair follicles, their disorders, and the principles behind developing treatments, reporting no new results.
42 citations
,
April 2008 in “Acta materialia” This study investigated the tensile response and morphological changes of different ethnic hair types using AFM, showing variations between virgin, chemically damaged, and conditioner-treated Caucasian hair under different conditions.
210 citations
,
February 2008 in “Nature genetics” This study found mutations in the P2RY5 gene that are linked to autosomal recessive woolly hair in Pakistani families, implicating it in hair texture determination.
37 citations
,
November 2007 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This review discusses how hair care practices impact hair breakage, particularly in patients of color, and reports no clinical results; the authors review testing and measurement advancements and highlight gaps in understanding structural differences.
85 citations
,
October 2007 in “International Journal of Dermatology” In this study, researchers found that the curliness of human hair is associated with an asymmetric structure at the cellular level, particularly in the differentiation of the precortex.
95 citations
,
October 2007 in “International Journal of Dermatology” This study found that human hair can be classified into eight main types based on objective measurements of shape, rather than ethnic categories, enhancing the understanding of hair diversity globally.
49 citations
,
September 2007 in “Journal of Investigative Dermatology” The study found that bioengineered hair follicles work when using cells from the same species but have issues when combining human and mouse cells.
55 citations
,
March 2007 in “Journal of cosmetic dermatology” This review discusses the historical development of hair straightening products for Afro-ethnic hair and reports no new research findings.
95 citations
,
January 2007 in “Human biology” This study proposes a new, objective method to classify human hair into eight categories based on specific shape measurements, rather than traditional ethnicity-based classifications.
62 citations
,
August 2006 in “Journal of Chromatography B” This article reviews the challenges in studying keratin proteins and emphasizes the potential of modern proteomic techniques to advance their research, but it reports no new findings.
65 citations
,
May 2006 in “Journal of Structural Biology” This study concluded that the curliness of human hair, regardless of ethnicity, originates from the inhomogeneous internal nanostructure due to differences in the distribution of two types of cortices.
224 citations
,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” This article discusses the hair follicle's regenerative cycles and the molecular mechanisms influencing them, emphasizing the need for therapeutic targeting of the "hair cycle clock" to manage hair growth disorders, without reporting new research findings.
291 citations
,
October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that rat whisker follicle stem cells can be expanded in culture and transplanted to form functional hair follicles, demonstrating their multipotency and potential for regenerative medicine.
26 citations
,
September 2005 in “International Journal of Dermatology” Hair shape is determined by genetic, molecular, and cellular factors.
479 citations
,
January 2005 in “BioEssays” This review introduces the morphological and molecular principles of hair follicle development but reports no new experimental results, focusing on recent insights and forming a working hypothesis.
40 citations
,
December 2004 in “Dermatology” This study suggests that an increase in kenogen phases, along with rising vellus hair cycles and fewer normal hair cycles, is associated with the progression of female androgenetic alopecia.
155 citations
,
August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution” This review discusses the conserved molecular mechanisms controlling hair follicle development and cycling and suggests they may also apply to other ectodermal derivatives, like teeth and feathers, but it reports no new results.
203 citations
,
June 2003 in “Journal of the American Academy of Dermatology” This article reviews the structure and chemistry of hair across ethnicities and how these factors affect hair properties and treatment responses, but reports no new research findings.
78 citations
,
June 2003 in “Journal of the American Academy of Dermatology” This article reviews the autonomous functioning and complex interactions within hair follicles, emphasizing their unique composition and differentiation pathways, but does not report new research findings.
90 citations
,
January 2002 in “Dermatology” This study describes the kenogen phase, where hair follicles rest after shedding, and finds its duration and frequency are greater in individuals with androgenetic alopecia, potentially contributing to baldness.
150 citations
,
July 2001 in “Clinics in dermatology” This article discusses hair care practices and hair cosmetics in managing alopecia but reports no new clinical findings; it emphasizes the importance of scalp health and good patient-physician communication.
51 citations
,
March 2001 in “Clinics in dermatology” This study found that bleach treatments significantly increased hair surface roughness and decreased Young's modulus, indicating marked changes in hair's molecular structure which may affect future hair-care product formulation.
949 citations
,
January 2001 in “Cell” This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.
59 citations
,
January 2001 in “Dermatology” This article discusses the role of dermatologists in advising patients on hair cosmetics and pharmaceuticals, highlighting the development of cosmeceuticals and the need for accurate information on health hazards associated with hair care products, but reports no new results.
1113 citations
,
August 1999 in “The New England Journal of Medicine” This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.
129 citations
,
June 1999 in “Archives of Dermatology” This study found that hair density is significantly lower in African Americans compared to whites, which may affect the evaluation and diagnosis of scalp biopsy specimens in this population.
86 citations
,
January 1996 in “Clinics in dermatology” This review discusses the effects of protein-based cosmetics on hair properties and reports no new research findings, suggesting potential benefits for developing advanced, sustainable hair products.
10 citations
,
January 1994 This study discusses that permanent hair straightening can be achieved at neutral or acidic pH conditions, with varying effects on cystine and lanthionine levels, by inducing supercontraction of the hair fiber.
38 citations
,
July 1993 in “Journal of Investigative Dermatology”