Proteome Analysis of Human Sebaceous Follicle Infundibula Extracted from Healthy and Acne-Affected Skin

    September 2014 in “ PLoS ONE ”
    Malene Bek-Thomsen, Hans B. Lomholt, Carsten Scavenius, Jan J. Enghild, Holger Brüggemann
    TLDR Acne-affected skin has more inflammation-related proteins and bacteria than healthy skin.
    This study aimed to understand acne vulgaris by analyzing sebaceous follicular casts from 18 healthy and 20 acne-affected individuals using mass spectrometry. It identified both human and bacterial proteins, revealing that normal skin was enriched with proteins like prohibitins and peroxiredoxins, which protect against stress. In contrast, acne-affected skin contained proteins related to inflammation, wound healing, and tissue remodeling, such as myeloperoxidase and vimentin. The study highlighted the significant role of the biological process 'response to a bacterium' in acne, with bacterial proteins exclusively from Propionibacterium acnes, including dermatan sulphate adhesins and CAMP factors. This was the first proteomic study to identify both human and skin microbiota proteins in sebaceous follicular casts.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 92 results

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  65 upvotes 2 years ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

      in Research/Science  134 upvotes 1 year ago
      The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  56 upvotes 8 months ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community 2 years of Androgen inhibition.

      in Progress Pictures  140 upvotes 3 months ago
      A 23-year-old has been using finasteride, dutasteride, and spironolactone to combat hair loss and hormonal acne, with mixed results and concerns about side effects. The user is experimenting with spironolactone despite its potential risks, hoping for skin and body hair improvements.

    Similar Research

    5 / 1000+ results