TLDR Telocytes might help with skin repair and regeneration.
The document from 2012 presents a study on the identification and potential function of telocytes (TCs) in human skin, particularly focusing on their role in skin regeneration. TCs, characterized by their long telopodes, were found in the dermis, especially around blood vessels, hair follicles, and glands, and were observed to form a 3D network. The study, which examined samples from three patients, used electron microscopy and immunofluorescence to show that TCs express markers such as c-kit/CD117 and CD34, and are in close contact with stem cells in the hair follicle bulge region. The findings suggest that TCs might contribute to skin homeostasis and regeneration by interacting with stem cells and other cells like mast cells. However, the precise nature of these interactions and the role of TCs in skin repair and regeneration require further investigation.
19 citations,
July 2011 in “Microscopy and Microanalysis” The hair follicle bulge is an important area for adult stem cells involved in hair growth and repair, with potential for medical use needing more research.
28 citations,
March 2010 in “Histochemistry and Cell Biology” Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.
788 citations,
February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
550 citations,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
14 citations,
February 2020 in “Scientific reports” Telocytes in the scalp may help with skin regeneration and maintenance.
8 citations,
January 2022 in “Burns and trauma” Skin cell-derived vesicles can help heal skin injuries effectively.
25 citations,
November 2014 in “Ageing Research Reviews” Skin aging is caused by stem cell damage and can potentially be delayed with treatments like antioxidants and stem cell therapy.
13 citations,
June 2020 in “Scientific reports” Melatonin stimulates the skin components of ram's scrotum during their non-breeding season.
10 citations,
January 2016 in “PLOS ONE” Researchers found 44 proteins that change during different hair growth stages and may be important for hair follicle function.
