Regional Variations in the Histology of Porcine Skin

November 2014 in “ Tissue Engineering Part C Methods ”

Neill J. Turner, Dominic J. Pezzone, Stephen F. Badylak

epidermal thickness dermal thickness hair follicle density collagen elastin type I collagen type III collagen

Studysummary This study found that while porcine skin resembles human skin, there are significant regional differences in skin composition and morphology, which could affect its use as a human analogue in research.

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The study evaluated the histological structure of porcine skin from 11 different anatomic regions in the American Yorkshire crossbreed, focusing on epidermal and dermal thickness, hair follicle density, and collagen and elastin composition and distribution. Significant regional differences were found, particularly in dermis and epidermis thickness and collagen and elastin content. Variations in type I and type III collagen distribution were also observed. These findings underscored the importance of recognizing regional differences in porcine skin to prevent misinterpretation when using it as a model for human skin.

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