TLDR Chronic inflammatory skin diseases are caused by disrupted interactions between skin cells and immune cells.
The paper discusses the epithelial-immune microenvironment (EIME) in chronic inflammatory skin diseases, focusing on atopic dermatitis (AD), psoriasis, systemic lupus erythematosus (SLE), alopecia areata (AA), and acne vulgaris. Dysregulation of interactions within the EIME can lead to inflammatory loops characteristic of these diseases. For example, AD involves type 2 inflammation with feedback loops between keratinocytes and immune cells, while psoriasis features a type 17 inflammatory loop driven by the IL-23-IL-17 axis. In AA, an inflammatory loop involving IFN-γ and IL-15 disrupts hair follicle immune privilege, leading to hair loss. The study highlights current treatments targeting these loops and suggests future therapeutic strategies.
Cited in this study
7 / 7 results
12 citations
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December 2022 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” New oral treatments for adult hair loss show promise, especially JAK inhibitors, with mild side effects.
40 citations
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August 2022 in “Frontiers in immunology” Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.
3 citations
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April 2022 in “Microorganisms” People with severe hair loss (Alopecia Areata) have different scalp bacteria than healthy people, which might help predict the condition's progress.
124 citations
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October 2019 in “Frontiers in Immunology” Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.
191 citations
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September 2018 in “British journal of dermatology/British journal of dermatology, Supplement” Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.
56 citations
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April 2017 in “Journal of dermatological science” New insights into the causes and treatments for the autoimmune hair loss condition Alopecia areata have been made.
701 citations
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August 2014 in “Nature medicine” Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.
October 2023 in “Acta dermato-venereologica (Print)” People with severe hair loss have lower zinc levels in their blood.
