Upregulation of SERPINB3/B4 and S100A7-9 in Hidradenitis Suppurativa/Acne Inversa

September 2019 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

D. Almansouri, Christos C. Zouboulis

SERPINB3 SERPINB4 S100A7 S100A8 S100A9 hidradenitis suppurativa acne inversa transglutaminase inhibitory proteins antimicrobial proteins epidermis hair follicle sheaths HS skin hair follicles

TLDR Certain proteins are significantly increased in the skin of people with hidradenitis suppurativa.

The study investigated the expression and localization of transglutaminase inhibitory proteins (SERPINB3/B4) and antimicrobial proteins (S100A7-A9) in hidradenitis suppurativa (HS). Analysis of gene expression from 8 affected patients and 4 healthy individuals revealed significant upregulation and downregulation of numerous genes in lesional vs. healthy skin. Specifically, SERPINB4, S100A8, and S100A9 were significantly overexpressed in lesional skin with average fold changes of 18.5, 23, and 28.3, respectively (n = 15). Immunohistochemistry confirmed the upregulation of these proteins in the epidermis and hair follicle sheaths of lesional tissues. These findings suggested new pathways in HS pathogenesis related to the disruption of essential cellular functions.

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