3D-SeboSkin Model for Human Ex Vivo Studies of Hidradenitis Suppurativa/Acne Inversa
June 2021
in “
Dermatology
”
Studysummary This study validated the HS 3D-SeboSkin model as a reliable tool for preclinical research, effectively preserving the structure and biomarker expression of lesional and perilesional HS skin ex vivo.
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The document describes the development of a human ex vivo model for Hidradenitis suppurativa/acne inversa (HS), a chronic inflammatory skin disease, using 3D-SeboSkin technology. This model was used to maintain skin explants from HS patients for 3 days, allowing for the study of the disease's pathophysiology and the testing of therapeutic candidates. The study involved a group of 9 female patients with a mean age of 37.2 ± 8.4 years. The model successfully preserved the structural integrity of lesional and perilesional HS skin and maintained the differential expression of several HS biomarkers (S100A9, KRT16, SERPINB3) in the skin tissues. The HS 3D-SeboSkin model was validated as a reproducible tool for preclinical studies of HS skin ex vivo.
