3D-SeboSkin Model Application in Hidradenitis Suppurativa/Acne Inversa

In 2019, a study developed a 3D-SeboSkin model to simulate Hidradenitis suppurativa/acne inversa (HS) using skin explants from HS patients co-cultured with SZ95 sebaceous gland cell cultures. The study involved 4 female patients with a median age of 42 years. The model preserved the epidermis structure better than skin specimens cultured alone and successfully reproduced the differential expression of HS biomarkers (S100A9, CK16, SERPINB3). The 3D-SeboSkin model was found to be reproducible and useful for future HS research, demonstrating the positive effects of combining HS skin explants with human sebocytes.