TLDR CRH promotes fat production in skin cells, affecting conditions like acne.
The study explored the role of corticotropin-releasing hormone (CRH) in human sebocytes, suggesting that CRH acts as an autocrine hormone promoting lipogenesis. CRH, along with its binding protein and receptors, was present in sebocytes, with CRH-R1 being the predominant receptor type. CRH increased sebaceous lipid synthesis and up-regulated specific enzyme mRNA levels without affecting cell viability or proliferation. Testosterone and growth hormone influenced CRH receptor expression, indicating a negative feedback mechanism. These findings linked CRH to conditions like acne, seborrhea, androgenetic alopecia, and other skin disorders related to sebaceous lipid alterations.
196 citations
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