Corticotropin-Releasing Hormone: An Autocrine Hormone That Promotes Lipogenesis in Human Sebocytes

    May 2002 in “ Proceedings of the National Academy of Sciences ”
    Christos C. Zouboulis, Holger Seltmann, Naoki Hiroi, WenChieh Chen, Maggie Young, Marina K. Oeff, Werner A. Scherbaum, Constantin E. Orfanos, Samuel M. McCann, Stefan R. Bornstein
    TLDR CRH promotes fat production in skin cells, affecting conditions like acne.
    The study examined the role of corticotropin-releasing hormone (CRH) in human sebocytes, finding that CRH acted as an autocrine hormone promoting lipogenesis. CRH, along with its binding protein and receptors, was expressed in sebocytes, with CRH-R1 being the predominant receptor. CRH increased sebaceous lipid synthesis without affecting cell viability or proliferation. Testosterone and growth hormone influenced CRH receptor expression, indicating a negative feedback mechanism. These findings suggested that CRH could be involved in conditions like acne, seborrhea, and androgenetic alopecia, due to its role in sebaceous lipid production.
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