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GlossaryLipogenesis

biological process converting excess carbs into stored fat

Lipogenesis is the biological process by which the body converts excess carbohydrates into fatty acids, which are then stored as fat. This process primarily occurs in the liver and adipose (fat) tissue and is crucial for energy storage and maintaining energy balance in the body.

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research Pharmacological Basis for Clinical Use of Antiandrogens

January 1983 in “Elsevier eBooks”

Cyproterone acetate is used to treat conditions like prostate cancer, early puberty, excessive sexual drive, and female androgenization by affecting androgen functions and suppressing certain hormones.

Behavior of the Two Circulating Androgens Testosterone and DHEA and Their Main Intracellular Metabolites in an Androgen-Sensitive Sebocyte Cell Line

research Behavior of the Two Circulating Androgens Testosterone and DHEA and Their Main Intracellular Metabolites in an Androgen-Sensitive Sebocyte Cell Line

April 2019 in “Journal of Investigative Dermatology”

Testosterone affects androgen receptors and lipid storage in cells, while DHEA does not convert to testosterone or affect these receptors in the same way.

Transgenic Erythropoietin Overexpression Inhibits Dermal Fat Formation and HIF1a in the Skin and Causes Telogen Effluvium in Mouse Pups During the First Hair Cycle

research Transgenic Erythropoietin Overexpression Inhibits Dermal Fat Formation and HIF1a in the Skin and Causes Telogen Effluvium in Mouse Pups During the First Hair Cycle

June 2024 in “Diabetes”

Erythropoietin overexpression disrupts hair growth and fat formation in mice.

research Dermal White Adipose Tissue Development and Metabolism: The Role of Transcription Factor Foxn1

September 2023 in “The FASEB journal”

Foxn1 is important for fat development, metabolism, and wound healing in skin.

research TGFβ Signaling Regulates Lipogenesis in Human Sebaceous Gland Cells

44 citations, January 2013 in “BMC Dermatology”

TGFβ signaling prevents sebaceous gland cells from producing fats.

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community How much would a high dose dutasteride scalp dht inhibition be?

in Finasteride/Dutasteride 10 upvotes 10 months ago

The conversation discusses the potential for high doses of dutasteride to completely inhibit scalp DHT and speculates whether this could cure baldness when combined with a topical antiandrogen. Specific dosages mentioned are 0.5 mg reducing scalp DHT by 55% and 2.5 mg by about 79%.

community A warning to those thinking about using Dutasteride

in Finasteride/Dutasteride 99 upvotes 4 years ago

The potential risks of long-term use of Dutasteride and how it may be linked to elevated liver enzymes, cholesterol levels, and decreased testosterone. Alternative treatments such as Finasteride and RU58841 were also discussed.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 6 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Efficacy of different dutasteride doses vs finasteride

in Research/Science 123 upvotes 1 year ago

Dutasteride doses matter for hair loss treatment and are more effective than finasteride. RU58841 is suggested for better gains, but side effect profiles should be considered.