Corticotropin-Releasing Hormone and the Skin
January 2006
in “
Frontiers in bioscience
”
corticotropin-releasing hormone CRH CRH receptors CRH-R1 CRH-R2 UV radiation hair cycle epidermal compartments dermal compartments cAMP IP3 Ca2+ PKA pathways PKC pathways NF-kappaB AP-1 CREB cell differentiation cell proliferation cell viability immune activity cutaneous CRH hypothalamo-pituitary-adrenal axis UVR PKA PKC
TLDR CRH in the skin acts like the body's stress response system, affecting cell behavior and immune activity.
The document reviewed the role of corticotropin-releasing hormone (CRH) in skin physiology and pathology, highlighting its production in the skin and its influence on various skin functions, including homeostasis, stress responses, and inflammatory processes. CRH and its receptors (CRH-R1 and CRH-R2) were involved in regulating immune responses, cell proliferation, differentiation, and hair follicle functions. The study suggested that CRH signaling in the skin was complex and similar to the hypothalamo-pituitary-adrenal axis, with potential therapeutic applications for treating skin disorders and conditions exacerbated by stress.
