Corticotropin-Releasing Hormone and the Skin

January 2006 in “ Frontiers in bioscience ”

Andrzej Słomiński

Studysummary This review discusses the role of corticotropin-releasing hormone in human skin, focusing on its regulation, receptors, and functions, and highlights parallels with the hypothalamo-pituitary-adrenal axis; it reports no new research findings.

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The document reviewed the role of corticotropin-releasing hormone (CRH) in skin physiology and pathology, highlighting its production in the skin and its influence on various skin functions, including homeostasis, stress responses, and inflammatory processes. CRH and its receptors (CRH-R1 and CRH-R2) were involved in regulating immune responses, cell proliferation, differentiation, and hair follicle functions. The study suggested that CRH signaling in the skin was complex and similar to the hypothalamo-pituitary-adrenal axis, with potential therapeutic applications for treating skin disorders and conditions exacerbated by stress.

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