Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of Alpha-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells

    August 2005 in “ Endocrinology ”
    Markus Böhm, Mareike Eickelmann, Zhuo Li … Thomas A. Luger
    Studysummary This study suggests that αMSH may play a regulatory role in human dermal papilla cells, potentially influencing immune and inflammatory responses in hair follicles, which could contribute to inflammatory alopecia.
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    Research cited in this study 7

    1. Spatiotemporal Expression, Distribution, and Processing of POMC and POMC-Derived Peptides in Murine Skin Journal of Histochemistry & Cytochemistry · 2000
    2. Down-Regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in Xenopus Melanophores Journal of Biological Chemistry · 1999
    3. Expression of Vascular Endothelial Growth Factor (VEGF) in Various Compartments of the Human Hair Follicle Archives of Dermatological Research · 1998
    4. Expression of Mu-Opiate Receptor in Human Epidermis and Keratinocytes Journal of Investigative Dermatology · 1998
    5. Adrenocorticotropic Hormone (ACTH) But Not Alpha-Melanocyte Stimulating Hormone (α-MSH) as a Mediator of Adrenalectomy-Induced Hair Growth in Mink Journal of Investigative Dermatology · 1998
    6. Drug-Induced Hair Loss and Hair Growth Drug Safety · 1994
    7. Proopiomelanocortin Expression in the Skin During Induced Hair Growth in Mice Experientia · 1992