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GlossaryMelanocortin 1 Receptor

regulates melanin production, affecting hair and skin color

The Melanocortin 1 Receptor (MC1R) is a protein found on the surface of melanocytes, the cells responsible for producing melanin, the pigment that gives skin, hair, and eyes their color. Variations in the MC1R gene can influence hair color, skin tone, and susceptibility to UV radiation, and are also associated with red hair and fair skin.

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research Finasteride Inhibits Melanogenesis Through the Regulation of Melanocortin 1 Receptor in Melanocytes

April 2015 in “한국생물공학회 학술대회”

Finasteride reduces melanin production in skin cells.

research Effect of Tribulus Terrestris Extract of Different Dosages on Melanocortin-1 Receptor Expression in Mouse Hair Follicles

January 2009 in “The Chinese Journal of Dermatovenereology”

Higher doses of Tribulus terrestris extract increase MC-1R expression in mouse hair follicles.

research Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of Alpha-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells

60 citations , August 2005 in “Endocrinology”

αMSH may help regulate immune responses in hair follicles and its disruption could lead to hair loss.

research Piecing Together the Pigment-Type Switching Puzzle

10 citations , November 2009 in “Pigment cell & melanoma research”

The document concludes that MGRN1 affects mouse fur color by interfering with a receptor's signaling, but its full role in the body is still unknown.

research EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling

59 citations , April 2016 in “Cell Reports”

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

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