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    Glossary Melanocortin 1 Receptor

    regulates melanin production, affecting hair and skin color

    The Melanocortin 1 Receptor (MC1R) is a protein found on the surface of melanocytes, the cells responsible for producing melanin, the pigment that gives skin, hair, and eyes their color. Variations in the MC1R gene can influence hair color, skin tone, and susceptibility to UV radiation, and are also associated with red hair and fair skin.

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    Research 30 of 403

    1. Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of α-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells Endocrinology · 2005 · 60 citations
    2. Finasteride Inhibits Melanogenesis throughthe Regulation of Melanocortin 1 Receptorin Melanocytes 한국생물공학회 학술대회 · 2015
    3. Effect of Tribulus Terrestris Extract of Different Dosings on Melanocortin-1 Receptor Expression in Mouse Hair Follicles The Chinese Journal of Dermatovenereology · 2009
    4. Expression of melanocortin receptors on cutaneous fibroblastic cells – collagen and beyond Experimental Dermatology · 2005 · 1 citations
    5. Selected variants of the melanocortin 4 receptor gene (MC4R) do not confer susceptibility to female pattern hair loss Archives of Dermatological Research · 2012 · 9 citations
    6. Down-regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in XenopusMelanophores Journal of Biological Chemistry · 1999 · 43 citations
    7. Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway Proceedings of the National Academy of Sciences · 2004 · 70 citations
    8. Melanocortin receptor type 2 (MC2R, ACTH receptor) expression in patients with alopecia areata Experimental Dermatology · 2010 · 22 citations
    9. An implication for post-transcriptional control: Reciprocal changes of melanocortin receptor type 2 mRNA and protein expression in alopecia areata Medical Hypotheses · 2010 · 7 citations
    10. Melanocortin receptors in fibroblastic cell types of the skin –<i>in vitro</i> and <i>in vivo</i> expression and functional relevance Experimental Dermatology · 2004 · 1 citations
    11. Melanocortins in fibroblast biology – current update and future perspective for dermatology Experimental Dermatology · 2004 · 32 citations
    12. Receptors in trichology: Hot spots for hair regeneration International journal of trichology · 2013
    13. EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling Cell Reports · 2016 · 59 citations
    14. AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis Cancer Research · 2023 · 24 citations
    15. Piecing together the pigment-type switching puzzle Pigment cell & melanoma research · 2009 · 10 citations
    16. Regrowth of black hair in two red‐haired alopecia areata patients Australasian Journal of Dermatology · 2012 · 5 citations
    17. Melanocytes and Vitiligo (and Hair Graying) Elsevier eBooks · 2014 · 1 citations
    18. The color of human hair Human health handbooks · 2012 · 1 citations
    19. Dissecting the Impact of α-MSH-MC1R-cAMP Signaling on UVA-Induced Stress in Fibroblasts - Implications for Regulation of Cutaneous Photoaging Aging and Disease · 2026
    20. Spectrum of Phenotypes Associated with Human MC1R Variations Albus Scientia · 2025
    21. Activity evaluation of epidermo-melanin unit and dermal damage in melasma UNESP Institutional Repository (São Paulo State University) · 2016
    22. The color of human hair 2011
    23. Local Actions of Thyrotropin-Releasing Hormone Regulate Hair Color Journal of Investigative Dermatology · 2011
    24. The Role of gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice International Journal of Molecular Sciences · 2019 · 2 citations
    25. Efficacy of an agonist of<i>α</i>-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation International Journal of Cosmetic Science · 2018 · 12 citations
    26. “Sebocytes’ makeup” - Novel mechanisms and concepts in the physiology of the human sebaceous glands 2011 · 58 citations
    27. 457 Impact of alpha-melanocyte-stimulating hormone on mitochondrial function in human dermal fibroblasts Journal of Investigative Dermatology · 2025
    28. Agouti and Agouti-related Protein: Analogies and Contrasts Journal of Biological Chemistry · 2000 · 135 citations
    29. Montagna Symposium 2013—Light and Skin: How Light Sustains, Damages, Treats, Images and Modifies Skin Biology 2014 · 1 citations
    30. FDA-Approved (Bremelanotide, Flibanserin) and Off-Label Medications (Testosterone, Sildenafil) to Enhance Sexual Desire/Function in Women Online journal of complementary & alternative medicine · 2020