Australasian Society for Dermatology Research Meeting, May 2006

October 2007 in “ Journal of Investigative Dermatology ”

SM Russell, MJ Ludford-Menting, Oliaro J Jane, Faruk Sacirbegovic, Ety Cheah, Natalie Pedersen, Serge Thomas, Anupama Pasam, Rosa M. Iazzolino, LE Dow, NE Waterhouse, Anthony B. Murphy, Sarah Ellis, MJ Smyth, MH Kershaw, PK Darcy, PO Humbert

female pattern hair loss FPHL MC1R gene Melanotan pemphigus COL17A1 gene keratinocyte-derived VEGF adipogenesis Grainyhead-like 3 E2F-1 glutathione peroxidase deficiency UVA radiation melanoma MC1R COL17A1 VEGF UVA

TLDR The meeting highlighted the genetic basis of female pattern hair loss and various skin health insights.

The 3rd Annual Scientific Meeting of the Australasian Society for Dermatology Research in 2006 presented key findings on various dermatological topics. Notably, the heritability of female pattern hair loss (FPHL) was highlighted with a heritability score of 0.75 in a pilot study and 0.69-0.86 in a larger study. Other significant studies included the role of MC1R gene variants in skin cancer risk, the protective effects of Melanotan on UV damage, and the pathophysiology and treatment of pemphigus. Research also linked COL17A1 gene mutations to dental abnormalities in non-herlitz junctional epidermolysis bullosa and identified a subpopulation of mammary stem cells with potential implications for breast cancer. Additionally, studies on keratinocyte-derived VEGF, adipogenesis, and the transcription factor Grainyhead-like 3 in mice provided insights into skin health, tissue engineering, and wound repair. The meeting also discussed the role of E2F-1 in squamous cell carcinoma, glutathione peroxidase deficiency in UV-induced SCC, and the photoprotective properties of UVA radiation. Genetic studies on melanoma underscored the clinical heterogeneity of melanoma susceptibility.

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