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GlossaryMelanocortin 1 Receptor (MC1R)

regulates melanin production, affecting hair and skin color

The Melanocortin 1 Receptor (MC1R) is a protein found on the surface of melanocytes, the cells responsible for producing melanin, the pigment that gives skin, hair, and eyes their color. Variations in the MC1R gene can influence hair color, skin tone, and susceptibility to UV radiation, and are also associated with red hair and fair skin.

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research Genetic Variation at the MC1R Locus and the Time Since Loss of Human Body Hair

152 citations, January 2004 in “Current anthropology”

Humans lost body hair relatively recently in evolution.

research EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling

59 citations, April 2016 in “Cell Reports”

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

research Regulation of Melanocyte Stem Cell Behavior by the Niche Microenvironment

24 citations, March 2018 in “Pigment Cell & Melanoma Research”

The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.

research Piecing Together the Pigment-Type Switching Puzzle

10 citations, November 2009 in “Pigment cell & melanoma research”

The document concludes that MGRN1 affects mouse fur color by interfering with a receptor's signaling, but its full role in the body is still unknown.

research Sox2 in the Dermal Papilla Regulates Hair Follicle Pigmentation

9 citations, July 2022 in “Cell reports”

Sox2 controls hair color by affecting pigment production in hair follicles.

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community PSA: Caffeine and Hair Transplants

in Transplants 28 upvotes 3 months ago

A user shared their experience with a hair transplant, emphasizing the importance of avoiding caffeine 7 days before the procedure. Ignoring this advice led to reduced effectiveness of the numbing agent, causing significant discomfort during the transplant.