The Hair Loss Encyclopedia

Resequencing Analyses Revealed Genetic Diversity and Selection Signatures During Rabbit Breeding and Improvement

March 2024 in “ Genes ”

Kerui Xie, Chao Ning, Aiguo Yang, Qin Zhang, Dan Wang, Xinzhong Fan

TLDR Genetic analysis of rabbits identified key genes for traits like coat color, body size, and fertility.

The study utilized whole-genome resequencing to analyze genetic diversity and selection signatures in 180 rabbits from 17 breeds, identifying 17,430,184 high-quality SNPs. It revealed distinct genetic clusters among breeds and pinpointed genes linked to key traits such as coat color (TYR, ASIP), fur structure (LIPH), body size (INSIG2, GLI3), fertility (EDNRA, SRD5A2), heat stress adaptation (PLCB1), and immune response (SEC31A, CD86, LAP3). The findings highlight the genetic basis of phenotypic diversification in rabbits, aiding breeding programs and conservation efforts.

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research Drivers of Plateau Adaptability in Cashmere Goats Revealed by Genomic and Transcriptomic Analyses

6 citations , August 2023 in “BMC genomics”

The study found that genetic differences related to hair growth and other traits help cashmere goats adapt to high-altitude environments.

research Msx2 Supports Epidermal Competency During Wound-Induced Hair Follicle Neogenesis

19 citations , June 2023 in “Journal of Investigative Dermatology”

The gene Msx2 is crucial for hair follicle regeneration during wound healing.

research CRISPR/Cas9-Mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

13 citations , March 2020 in “Genes”

Disrupting the FGF5 gene in rabbits leads to longer hair by extending the hair growth phase.

research Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness

51 citations , November 2011 in “British Journal of Dermatology”

A gene called HDAC9 might be a new factor in male-pattern baldness.

research Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation

67 citations , February 2009 in “Developmental Biology”

Msx2 and Foxn1 are both crucial for hair growth and health.