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GlossaryAgouti Signaling Protein (ASIP)

protein influencing hair color by inhibiting melanocortin 1 receptor

Agouti Signaling Protein (ASIP) is a protein that plays a crucial role in determining hair color in mammals. It works by inhibiting the action of the melanocortin 1 receptor (MC1R), which leads to the production of yellow or red pigments (pheomelanin) instead of black or brown pigments (eumelanin). This protein is also involved in various biological processes, including energy metabolism and obesity.

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research Comparative Genome Analyses Reveal the Unique Genetic Composition and Selection Signals Underlying the Phenotypic Characteristics of Three Chinese Domestic Goat Breeds

30 citations , November 2019 in “Genetics selection evolution”

Chinese domestic goats have unique genetic traits due to domestication and geographic isolation.

research Efficacy of an Agonist of α-MSH, the Palmitoyl Tetrapeptide-20, in Hair Pigmentation

12 citations , September 2018 in “International Journal of Cosmetic Science”

Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.

research Piecing Together the Pigment-Type Switching Puzzle

10 citations , November 2009 in “Pigment cell & melanoma research”

The document concludes that MGRN1 affects mouse fur color by interfering with a receptor's signaling, but its full role in the body is still unknown.

research Siberian Cats Help in Solving Part of the Mystery Surrounding Golden Cats

7 citations , May 2021 in “Animal Genetics”

The CORIN gene variant causes the golden color in Siberian cats.

research Associations Between Sun Sensitive Pigmentary Genes and Serum Prostate Specific Antigen Levels

4 citations , March 2018 in “PloS one”

Men with less sun-sensitive skin have lower PSA levels, while men with more sun-sensitive skin have higher PSA levels.

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community Scientists May Have Accidentally Found a Way to Reverse Hair Loss Without Drugs

in Research/Science 880 upvotes 3 months ago

2-deoxy-D-ribose is being explored as a hair loss treatment but is not proven effective in humans and may be costly and inconvenient. Minoxidil remains the most effective treatment.

community Just found out I am Vitamin D deficient

in Treatment 58 upvotes 3 years ago

A user found out they are vitamin D deficient and was prescribed high-dose vitamin D supplements, asking if others had similar experiences and if it improved their hair. Some shared improved mood and testosterone levels after treatment, while another combined vitamin D supplements with finasteride due to family history of baldness.

community One year progress pics, fin only

in Progress Pictures 421 upvotes 1 year ago

The user showed a one-year hair regrowth progress using finasteride only, after stopping minoxidil due to its toxicity to cats. They noticed hair growth around six or seven months into treatment.