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research Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

508 citations , June 2009 in “Current drug metabolism”

This review details the skin and hematological toxicities of tyrosine kinase inhibitors like erlotinib, gefitinib, and imatinib, and highlights ongoing concerns about cardiac toxicity, reporting no new clinical findings.

research Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases

88 citations , August 2019 in “Frontiers in immunology”

This review discusses the role of tyrosine kinase signaling pathways in autoimmune and inflammatory skin diseases and reports no new clinical results, highlighting ongoing research into small-molecule tyrosine kinase inhibitors as potential treatments.

research Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency.

74 citations , July 1995 in “PubMed”

This study suggests that reversible hypopigmentation in homocystinuric patients may result from tyrosinase inhibition by homocyst(e)ine, with in-vitro experiments showing copper sulfate reversing this inhibition.

research Tyrosine kinase inhibition and grey hair

59 citations , March 2003 in “The Lancet”

Imatinib can repigment grey hair, while SU11428 can cause temporary hair depigmentation.

research Unique Cutaneous Reaction to Second- and Third-Generation Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia

32 citations , September 2015 in “Dermatology”

This study describes a newly recognized skin reaction associated with dasatinib, nilotinib, and ponatinib, marked by a lichenoid exanthem with severe pruritus that may necessitate discontinuation of therapy.

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Learn

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learn L-Tyrosine HCL

learn Acetyl Tyrosine

learn taurine

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Community Join

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community Beneficial supplement (my experience)

1 upvotes 8 months ago

The user shares their experience with hair loss treatments, specifically finasteride, and discusses the side effects like lowered libido and motivation. They recommend trying tyrosine to counter these effects, noting it improved their libido and energy levels.

community Has anyone with high prolactin taken meds to lower it and seen hair regrowth?

5 upvotes 8 months ago

High prolactin levels may contribute to hair loss, and some users suggest supplements like mucuna pruriens, vitamin B6, vitamin E, L-Tyrosine, L-Theanine, DIM, and Zinc to lower prolactin. Lifestyle changes to increase dopamine, such as reducing screen time and stress, are also recommended.

community Hair Restoration Log (Weekly 1.5 mm microneedling + QOD 0.5 mg Finasteride + Daily 50 mg 5% RU58841)

2 upvotes 5 years ago

The user experienced side effects from daily 1 mg Finasteride and switched to 0.5 mg every other day, supplemented with creatine, tongkat ali, tribulus terrestris, vitamin D3, bromantane, l-tyrosine, and caffeine. They also use weekly 1.5 mm microneedling and daily 50 mg RU58841, except on microneedling days, to manage hair loss.

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Experts

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Clinics

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