Ultraviolet B Irradiation Increases the Expression of Inflammatory Cytokines in Cultured Sebocytes

December 2013 in “ Journal of Dermatology ”

Weon Ju Lee, Kyung Hea Park, Mi Yeung Sohn, Won Chae Lee, Seok Jong Lee, Do Won Kim

UV-B irradiation inflammatory cytokines sebocytes sebaceous glands IL-1ß IL-6 IL-8 TNF-α acne UV-B inflammation skin cells oil glands interleukin-1 beta interleukin-6 interleukin-8 tumor necrosis factor alpha pimples

Studysummary This study found that UV-B exposure significantly increased the expression of inflammatory cytokines IL-1β and IL-8 in cultured sebocytes.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Vitamin D Increases Expression of Cathelicidin in Cultured Sebocytes

18 citations , June 2012 in “Archives of Dermatological Research”

This study found that treatment with vitamin D increased the expression of LL-37 through the vitamin D receptor in cultured sebocytes.

research Effect of Dihydrotestosterone on the Upregulation of Inflammatory Cytokines in Cultured Sebocytes

32 citations , December 2009 in “Archives of Dermatological Research”

In this study, DHT was associated with increased production of proinflammatory cytokines IL-6 and TNF-α in cultured sebocytes, suggesting a role in acne pathophysiology beyond sebum production.

research Human Skin Stem Cells and the Aging Process

143 citations , September 2008 in “Experimental gerontology”

This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.

research Influence of Substance P on Cultured Sebocytes

46 citations , April 2008 in “Archives of Dermatological Research”

This study found that substance P may be involved in the pathogenesis of acne by increasing the expression of certain cytokines and receptors in cultured sebocytes.

research Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications

30 citations , April 2007 in “Dermatologic Clinics”

This review discusses the mechanisms by which isotretinoin and hormonal therapy treat acne through their effects on sebaceous glands, reporting no new clinical results.

research Acne and Sebaceous Gland Function

463 citations , September 2004 in “Clinics in dermatology”

This review discusses the development, function, and complex roles of sebaceous glands in acne and suggests future acne treatments should target inflammation and lipid production; it reports no new clinical results.

research Human Skin Is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1)

289 citations , May 2003 in “Journal of Investigative Dermatology”

This study demonstrates that human skin is capable of steroid hormone synthesis, but its role in androgenic skin disorders like acne and alopecia is yet to be clarified.

research Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin

196 citations , May 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that SZ95 sebocytes and HaCaT keratinocytes exhibit distinct enzyme expressions and activities, implicating their different roles in androgen metabolism and homeostasis in vitro.