New Approach to the Understanding of Keloid: Psychoneuroimmune-Endocrine Aspects

    Felipe Contoli Isoldi, Bernardo Hochman, Fabianne Furtado, Lydia Masako Ferreira
    Studysummary This review explores the "brain-skin connection" and presents evidence suggesting keloids may be influenced by psychosocial stress, although it reports no new experimental results.
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    Research cited in this study 11

    1. Prolactin: An Emerging Force Along the Cutaneous–Endocrine Axis Trends in Endocrinology and Metabolism · 2010
    2. Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ The FASEB Journal · 2010
    3. Melatonin in the Skin: Synthesis, Metabolism, and Functions Trends in Endocrinology and Metabolism · 2008
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    5. Neuroimmunology of Stress: Skin Takes Center Stage Journal of Investigative Dermatology · 2006
    6. Neuroimmunoendocrine Circuitry of the Brain-Skin Connection Trends in Immunology · 2005
    7. Stress and Psychoneuroimmunologic Factors in Dermatology Dermatologic Clinics · 2005
    8. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    9. Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia Journal of Investigative Dermatology · 2004
    10. Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen American Journal of Pathology · 2003
    11. Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin and Hair Growth Modulation by Neuropeptides Journal of Investigative Dermatology · 2001