56 citations
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January 2022 in “Burns & Trauma” This study suggests that intercellular communication via the WNT5A and STAT pathways may partly drive EMT-like phenomena in keloid pathogenesis, based on findings in an animal model.
July 2025 in “Journal of Investigative Dermatology” Schwann cell and M2 macrophage interactions contribute to keloid growth by increasing matrix deposition.
May 2023 in “Research Square (Research Square)” This study observed that the Hedgehog-GLI1 signaling pathway is upregulated in keloid patient–derived stem cells, and inhibiting this pathway reduced keloid characteristics in both mice and ex vivo tissue cultures, suggesting potential therapeutic targets for keloid treatment.
April 2026 in “Biomedicines” This study introduces a novel holistic treatment approach for keloid that combines systemic therapies, including Traditional Chinese Medicine, with local interventions to target the inflammatory microenvironment and keloid predisposition for improved management and prevention of recurrence.
This study found that a single 8Gy dose of superficial 50kV X-ray radiation minimizes keloid recurrence after excision, and identified genomic pathways and potential molecular targets for improved keloid therapy.
