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    Glossary Keloids

    raised, thickened scar tissue that extends beyond original wounds

    Keloids are raised, thickened areas of scar tissue that form at the site of skin injury, such as cuts, burns, or surgical incisions. Unlike regular scars, keloids extend beyond the original wound boundaries and can continue to grow over time. They are the result of an overproduction of collagen during the healing process and can be itchy, painful, or cause discomfort. Keloids are more common in individuals with darker skin tones and can be challenging to treat, often requiring a combination of therapies such as corticosteroid injections, laser treatment, or surgical removal.

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    1. Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids International journal of molecular sciences · 2018 · 305 citations
    2. WNT5A drives interleukin-6-dependent epithelial–mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis Burns & Trauma · 2022 · 56 citations
    3. Epithelial–mesenchymal transition in keloid tissues and TGF‐β1–induced hair follicle outer root sheath keratinocytes Wound repair and regeneration · 2015 · 46 citations
    4. Acne Keloidalis Nuchae American Journal of Clinical Dermatology · 2010 · 40 citations
    5. Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan BMJ Open · 2018 · 35 citations
    6. Keratosis Follicularis Spinulosa Decalvans Associated with Acne Keloidalis Nuchae and Tufted Hair Folliculitis American Journal of Clinical Dermatology · 2008 · 35 citations
    7. The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease Journal of Investigative Dermatology · 2016 · 31 citations
    8. New approach to the understanding of keloid: psychoneuroimmune–endocrine aspects Clinical Cosmetic and Investigational Dermatology · 2015 · 21 citations
    9. A Novel Treatment of Acne Keloidalis Nuchae by Long-Pulsed Alexandrite Laser Dermatologic Surgery · 2017 · 19 citations
    10. Hypoxia macrophage-derived exosomal miR-26b-5p targeting PTEN promotes the development of keloids Burns & Trauma · 2024 · 17 citations
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    1. What Are the Technicalities of Curved Hair Transplantation? Reddit · 26 Mar 2026

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