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    Glossary Keloids

    raised, thickened scar tissue that extends beyond original wounds

    Keloids are raised, thickened areas of scar tissue that form at the site of skin injury, such as cuts, burns, or surgical incisions. Unlike regular scars, keloids extend beyond the original wound boundaries and can continue to grow over time. They are the result of an overproduction of collagen during the healing process and can be itchy, painful, or cause discomfort. Keloids are more common in individuals with darker skin tones and can be challenging to treat, often requiring a combination of therapies such as corticosteroid injections, laser treatment, or surgical removal.

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    1. Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids International journal of molecular sciences · 2018 · 305 citations
    2. WNT5A drives interleukin-6-dependent epithelial–mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis Burns & Trauma · 2022 · 56 citations
    3. Epithelial–mesenchymal transition in keloid tissues and TGF‐β1–induced hair follicle outer root sheath keratinocytes Wound repair and regeneration · 2015 · 46 citations
    4. Acne Keloidalis Nuchae American Journal of Clinical Dermatology · 2010 · 40 citations
    5. Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan BMJ Open · 2018 · 35 citations
    6. Keratosis Follicularis Spinulosa Decalvans Associated with Acne Keloidalis Nuchae and Tufted Hair Folliculitis American Journal of Clinical Dermatology · 2008 · 35 citations
    7. The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease Journal of Investigative Dermatology · 2016 · 31 citations
    8. New approach to the understanding of keloid: psychoneuroimmune–endocrine aspects Clinical Cosmetic and Investigational Dermatology · 2015 · 21 citations
    9. A Novel Treatment of Acne Keloidalis Nuchae by Long-Pulsed Alexandrite Laser Dermatologic Surgery · 2017 · 19 citations
    10. Hypoxia macrophage-derived exosomal miR-26b-5p targeting PTEN promotes the development of keloids Burns & Trauma · 2024 · 17 citations
    11. Identification and characterization of four immune-related signatures in keloid Frontiers in Immunology · 2022 · 11 citations
    12. [Methotrexate to treat SAPHO syndrome with keloidal scars]. PubMed · 2011 · 10 citations
    13. Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids Journal of Cosmetic Dermatology · 2022 · 9 citations
    14. Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model International Wound Journal · 2023 · 8 citations
    15. Extensive donor site keloids in follicular unit extraction hair transplantation International Journal of Trichology · 2017 · 7 citations
    16. Single‐cell RNA sequencing highlights the role of proinflammatory fibroblasts, vascular endothelial cells, and immune cells in the keloid immune microenvironment International Journal of Dermatology · 2024 · 6 citations
    17. Clinical description of a rare dermatological disease, acne Keloidalis Nuchae, and successful homoeopathic management: A case report International Journal of Homoeopathic Sciences · 2021 · 5 citations
    18. Keloid scars arising after follicular unit extraction hair transplantation Journal of Cutaneous and Aesthetic Surgery · 2020 · 4 citations
    19. Gut microbiota-derived metabolites in keloid and hypertrophic scarring Frontiers in Microbiology · 2025 · 3 citations
    20. Keloids in male genitalia—Systematic review and illustrative case report Wound Repair and Regeneration · 2024 · 3 citations
    21. Keloids After Herpes Zoster: Report of Wolf’s Isotopic Phenomenon and Literature Review Clinical Cosmetic and Investigational Dermatology · 2023 · 3 citations
    22. Androgen-related disorders and hormone therapy for patients with keloids Chinese Journal of Plastic and Reconstructive Surgery · 2022 · 3 citations
    23. Transient chemotherapy-induced alopecia after intralesional 5-fluorouracil treatment of keloids JAAD Case Reports · 2019 · 3 citations
    24. Why don't we have more effective treatment for keloids? PubMed · 2010 · 3 citations
    25. A Signature of Genes Featuring FGF11 Revealed Aberrant Fibroblast Activation and Immune Infiltration Properties in Keloid Tissue Emergency medicine international · 2022 · 2 citations
    26. Keloid Formation and Any Skin Complications in Patients Treated With Isotretinoin and Undergone Any Skin‐Related Procedures Journal of Cosmetic Dermatology · 2024 · 1 citations
    27. Single cell deciphering of pruritic keloids: the interaction between fibroblasts and Schwann cells through the Midkine signaling Burns & Trauma · 2025 · 1 citations
    28. Catecholaminergic neurons boost fibroblast osteogenic activity in keloid Nature Communications · 2026
    29. LB1028 Spontaneous keloid eruption in a patient on dialysis Journal of Investigative Dermatology · 2024
    30. LB923 A matched cohort study evaluating the risk of keloid development in alopecia areata patients Journal of Investigative Dermatology · 2024