Identification and Characterization of Four Immune-Related Signatures in Keloid

    July 2022 in “ Frontiers in Immunology ”
    Xiaoxiang Wang, Bo Liang, Jiehua Li, Xiaobing Pi, Peng Zhang, Xinzhu Zhou, Xiaohong Chen, Sitong Zhou, Ronghua Yang
    Studysummary This study identified four immune-related signaling molecules (LGR5, PTN, JAG1, and DKK1) associated with keloid, suggesting their potential role in its pathogenesis and as targets for new treatments. Our plain-language summary of this paper — not a Tressless recommendation.
    This study identified four immune-related genes (LGR5, PTN, JAG1, and DKK1) associated with keloid formation through bioinformatic analysis of three public datasets and clinical validation with 15 patients. The genes showed distinct patterns of immune cell infiltration, with DKK1 and PTN being downregulated and JAG1 and LGR5 upregulated in keloid tissues. These findings suggest that these genes play significant roles in keloid pathogenesis and could be potential therapeutic targets, although further research is needed to validate these results.
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