Identification and Characterization of Four Immune-Related Signatures in Keloid

July 2022 in “ Frontiers in Immunology ”

Xiaoxiang Wang, Bo Liang, Jiehua Li, Xiaobing Pi, Peng Zhang, Xinzhu Zhou, Xiaohong Chen, Sitong Zhou, Ronghua Yang

keloid LGR5 PTN JAG1 DKK1 immune cell infiltration bioinformatic analysis

TLDR Four specific genes are linked to keloid formation and could be potential treatment targets.

This study identified four immune-related genes (LGR5, PTN, JAG1, and DKK1) associated with keloid formation through bioinformatic analysis of three public datasets and clinical validation with 15 patients. The genes showed distinct patterns of immune cell infiltration, with DKK1 and PTN being downregulated and JAG1 and LGR5 upregulated in keloid tissues. These findings suggest that these genes play significant roles in keloid pathogenesis and could be potential therapeutic targets, although further research is needed to validate these results.

View this study on frontiersin.org →

Discuss this study in the Community →

Similar Research

5 / 825 results

research Fibroproliferative Genes Are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia

25 citations, June 2018 in “Journal of The American Academy of Dermatology”

Genes linked to fibrosis are more active in people with central centrifugal cicatricial alopecia.

research TNC+ Fibroblasts Involved in Skin Inflammation via Neuro-Immune Interactions with T Cells

September 2023 in “Research Square (Research Square)”

TNC+ fibroblasts play a key role in skin inflammation by interacting with T cells.

research Skin Fibroblast Functional Heterogeneity in Health and Disease

1 citations, August 2023 in “The Journal of Pathology”

Different types of skin fibroblasts have unique roles in skin health and disease.

research Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions

178 citations, August 2016 in “Advances in wound care”

New effective scar treatments are urgently needed due to the current options' limited success.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations, May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Identification and Characterization of Four Immune-Related Signatures in Keloid

Related Community Posts Join

community Verteporfin Update Dr Barghouthi (prevents scars, potential regrowth)

community 148 Days Minoxidil+Finasteride Topical, Keto Shampo 2x Weekly

community 11 Months Topical Fin 0.3%+Min 6% daily, Last 2 Months Added Min 5% Foam at Night, Late 30s Male Progress

community Verteporfin update - donor hair regeneration human trial

community Verteporfin day 119 update - donor hair regeneration human trial