Discovery of Potential Hub Genes and Pathways in Keloid Fibroblast Development Based on Bioinformatics Analysis

January 2025 in “ International Journal of Genomics ”

Boao Zhao, Wei Zhang, Wende Yao, Xinyi Li, Tao Yang, Hui Cheng, Xiaojing Li, Xiaojing Li, Xiaojing Li

keloid fibroblast BMP4 POSTN WNT5A biomarkers hyperplasia

TLDR Three genes, BMP4, POSTN, and WNT5A, may help treat keloids.

This study identified three hub genes—BMP4, POSTN, and WNT5A—that are closely linked to keloid fibroblast hyperplasia and may serve as potential biomarkers for inhibiting this condition. The findings suggest that these genes could be targeted in future therapeutic strategies, although further molecular and animal studies are necessary to fully understand the mechanisms involved in keloid development.

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