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GlossaryCorticotropin-Releasing Hormone (CRH)

peptide hormone that triggers stress response via ACTH release

Corticotropin-Releasing Hormone (CRH) is a peptide hormone involved in the stress response. It is produced by the hypothalamus and stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH), which in turn prompts the adrenal glands to produce cortisol, a key stress hormone. CRH also plays a role in various bodily functions, including immune response and skin health, and has been linked to conditions like alopecia, where stress can exacerbate hair loss.

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New Effects of Caffeine on Corticotropin-Releasing Hormone (CRH)-Induced Stress Along the Intrafollicular Classical Hypothalamic-Pituitary-Adrenal (HPA) Axis (CRH-R1/2, IP3-R, ACTH, MC-R2) and the Neurogenic Non-HPA Axis (Substance P, p75NTR and TrkA) in Ex Vivo Human Male Androgenetic Scalp Hair Follicles

research New Effects of Caffeine on Corticotropin-Releasing Hormone (CRH)-Induced Stress Along the Intrafollicular Classical Hypothalamic-Pituitary-Adrenal (HPA) Axis (CRH-R1/2, IP3-R, ACTH, MC-R2) and the Neurogenic Non-HPA Axis (Substance P, p75NTR and TrkA) in Ex Vivo Human Male Androgenetic Scalp Hair Follicles

12 citations, April 2020 in “British Journal of Dermatology”

Caffeine may help reduce stress-induced hair loss.

research CRH Receptor Antagonists From Pulsatilla Chinensis Prevent CRH-Induced Premature Catagen Transition In Human Hair Follicles

9 citations, February 2020 in “Journal of Cosmetic Dermatology”

Pulsatilla chinensis compounds may help prevent stress-related hair loss.

research Gene Polymorphisms and Serum Levels of BDNF and CRH in Vitiligo Patients

July 2022 in “PLOS ONE”

Certain gene variations and different levels of BDNF and CRH hormones are linked to vitiligo.

research Corticotropin-Releasing Hormone and the Skin

137 citations, January 2006 in “Frontiers in bioscience”

CRH in the skin acts like the body's stress response system, affecting cell behavior and immune activity.

research Does the Corticotropin-Releasing Hormone System Play a Role in the Pathogenesis of Lichen Planus?

January 2017 in “Postepy Dermatologii I Alergologii”

The CRH/CRH-R1 system might be involved in causing lichen planus.

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community How does hair loss and recovery work?

in Chat 12 upvotes 5 months ago

Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

community 2 years on oral fin and oral min, 20M

in Progress Pictures 2037 upvotes 7 months ago

A 20-year-old shared progress pictures after 2 years of using oral finasteride and oral minoxidil for hair loss. Responses included admiration and requests for more details and updates.

community Any other females with no family history of hair loss?

in Female 6 upvotes 6 years ago

A female experiencing premature full-blown male pattern baldness with no family history of hair loss, and other users sharing their experiences.