Caffeine Relaxes Hair Follicles in Androgenetic Alopecia

August 2020 in “ British Journal of Dermatology ”

Masaru Ohyama

caffeine androgenetic alopecia corticotropin-releasing hormone hair follicles hair thinning AGA CRH

Studysummary Caffeine may protect hair follicles from stress-related hair loss.

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New Effects of Caffeine on Corticotropin-Releasing Hormone (CRH)-Induced Stress Along the Intrafollicular Classical Hypothalamic-Pituitary-Adrenal (HPA) Axis (CRH-R1/2, IP3-R, ACTH, MC-R2) and the Neurogenic Non-HPA Axis (Substance P, p75NTR and TrkA) in Ex Vivo Human Male Androgenetic Scalp Hair Follicles

research New Effects of Caffeine on Corticotropin-Releasing Hormone (CRH)-Induced Stress Along the Intrafollicular Classical Hypothalamic-Pituitary-Adrenal (HPA) Axis (CRH-R1/2, IP3-R, ACTH, MC-R2) and the Neurogenic Non-HPA Axis (Substance P, p75NTR and TrkA) in Ex Vivo Human Male Androgenetic Scalp Hair Follicles

12 citations , April 2020 in “British Journal of Dermatology”

In this study, researchers found that caffeine can counteract stress-induced damage in ex vivo human androgenetic alopecia hair follicles, suggesting it may help prevent stress-related hair loss.

research The Contribution of Endogenous and Exogenous Factors to Male Alopecia

37 citations , April 2013 in “Plastic and Reconstructive Surgery”

This study found that environmental factors such as smoking, alcohol consumption, exercise, and testosterone levels may significantly influence various forms of hair loss in male identical twins.

research The Role of Hair Follicles in the Percutaneous Absorption of Caffeine

182 citations , December 2007 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

This study demonstrated that hair follicles significantly expedite the absorption of caffeine through the skin compared to interfollicular pathways.

research Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro

114 citations , January 2007 in “International Journal of Dermatology”

This study found that caffeine can stimulate hair growth in vitro and counteract testosterone-induced growth suppression in hair follicles from male AGA patients.

research Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol

489 citations , June 2005 in “The FASEB Journal”

This study found that human scalp hair follicles can respond to corticotropin releasing hormone stimulation similarly to the classical HPA axis, including up-regulating cortisol production and activating neuroendocrine feedback loops.

research Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia

162 citations , August 2004 in “Journal of Investigative Dermatology”

This study suggests that stress negatively affects hair growth by inducing inflammation and early hair cycle transitions in mice, which might inform strategies for managing stress-related hair loss in humans.