Does the Corticotropin-Releasing Hormone System Play a Role in the Pathogenesis of Lichen Planus?

This study suggests that the expression and localization of toll-like receptors and caveolin-1 in lichen planopilaris may influence cicatricial alopecia pathobiology and that downregulating caveolae could offer a novel management strategy.

This study reported an incidence of lichen planus of 0.16% among patients, with the classical type being most common, and found associations with various immune-mediated diseases and rare cases of malignant transformation.

In this research, RNA expression analysis of scalp biopsies from lichen planopilaris patients revealed changes in specific genes after treatments with hydroxychloroquine, narrow band UVB, or low level laser light therapy, suggesting potential biomarkers and implicating M2 macrophages in the disease's immunopathogenesis.

This article reviews the pathogenesis, complications, and management of lichen planus, especially its persistent oral form, and highlights the need for further prospective studies.

This extensive review discusses the clinical manifestations, potential associations, and treatment approaches for lichen planus, but reports no new clinical results, highlighting gaps in evidence for therapeutic strategies.