Does the Corticotropin-Releasing Hormone System Play a Role in the Pathogenesis of Lichen Planus?

    January 2017 in “ Postepy Dermatologii I Alergologii ”
    Bengü Çevirgen Cemil, Demet Yılmazer, Hatice Ataş, Fatma Pelin Cengiz, Filiz Canpolat, Murat Alper, Müzeyyen Gönül
    Image of study
    TLDR The CRH/CRH-R1 system might be involved in causing lichen planus.
    In 2017, a study involving 32 patients with lichen planus (LP) and 17 controls investigated the expression of corticotropin-releasing hormone receptor type 1 (CRH-R1) in LP lesions. The study used immunohistochemical staining and found a significant increase in CRH-R1 expression in LP lesions compared to control skin (p < 0.05). However, no correlation was observed between the intensity of CRH-R1 staining and the body surface area affected by LP, nor with age, disease duration, gender, or oral involvement. These results suggest that the CRH/CRH-R1 system may be involved in the pathogenesis of LP, indicating a potential role for CRH-R1 in the disease's etiology, independent of its severity.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    2 / 2 results

      community How does hair loss and recovery work?

      in Chat  12 upvotes 1 year ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community Result of my cortisol, prolactin, testosterone, ACTH blood test,

      in Update 1 week ago
      OP is using 5% minoxidil and a foligain supplement for hair loss, with blood test results showing high cortisol levels. OP is considering starting finasteride, while another user shares their experience with finasteride and hair loss challenges due to malabsorption issues.

    Similar Research

    5 / 553 results