Spatiotemporal Expression, Distribution, and Processing of POMC and POMC-Derived Peptides in Murine Skin

    July 2000 in “ Journal of Histochemistry & Cytochemistry ”
    Joseph E. Mazurkiewicz, David Corliss, Andrzej Słomiński
    TLDR POMC-derived peptides are important for skin functions like immune response and stress management.
    The study investigated the expression and processing of pro-opiomelanocortin (POMC) and its derived peptides in murine skin during the hair cycle, particularly following depilation-induced anagen. It was found that POMC mRNA and peptide levels, including ACTH, β-endorphin, β-MSH, and α-MSH, increased during anagen and varied among different cell types, such as keratinocytes and sebocytes. The presence of prohormone convertases PC1 and PC2 suggested their role in the differential processing of POMC. The study concluded that POMC-derived peptides might play significant roles in skin physiology, including immune modulation and stress responses, and highlighted the complex regulation of these peptides in relation to the hair cycle.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 339 results

      community Koshine826 PRO 1% is available

      in Chat  36 upvotes 1 year ago
      The conversation is about the availability of Koshine826 PRO 1% for hair loss treatment. The discussion includes Minoxidil, finasteride, and RU58841.

      community Nutrafol Women’s Balance vs Viviscal Pro?

      in Female  2 upvotes 2 weeks ago
      OP experienced thicker hair and less shedding with Nutrafol Women’s Balance but had flushing due to ingredients, and is considering switching to Viviscal Pro with saw palmetto. A user shared that Viviscal increased shedding for both him and his girlfriend, and suggested stopping Nutrafol if the hair loss is due to Telogen effluvium.

      community I asked Gemini 2.5 Pro to roast r/tressless

      in Satire  35 upvotes 7 months ago
      Hair loss concerns and treatments like Minoxidil and Finasteride are humorously discussed. The community's quirks and dedication to battling hair loss are highlighted.

      community How I started reversing Male Pattern Baldness naturally ?

      in Question  10 upvotes 8 years ago
      The user reversed male pattern baldness using a pro-thyroid diet, lifestyle changes, and scalp stimulation exercises, without Minoxidil or Finasteride. They reported reduced dandruff, itchiness, oiliness, and experienced hair regrowth and thickening over 15 months.

    Similar Research

    5 / 1000+ results