Recent Advances in Neuropeptide-Related Omics and Gene Editing: Spotlight on NPY and Somatostatin and Their Roles in Growth and Food Intake of Fish

The document discusses the use of omics technology and gene editing in studying the function of neuropeptides, specifically Neuropeptide Y (NPY) and somatostatin (SS), in relation to growth and food intake in fish. NPY promotes feeding while SS inhibits it. Gene editing technologies, including CRISPR/Cas9, have been used to construct knockout models of these neuropeptides and their receptors in mammals and zebrafish. NPY family receptors are highly expressed in various organs of teleost fish and NPY can stimulate food intake in various fish species. SS, on the other hand, inhibits the basal and induced growth hormone secretion in the pituitary of various teleost fish. The document also discusses the interaction between neuropeptides in the regulation of feeding. The authors note the need for more studies on non-mammalian animals. The research was supported by the National Key R&D Program of China, China Agriculture Research System, and National Science Foundation of China.