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GlossaryNeuropeptides

small protein-like molecules that neurons use to communicate

Neuropeptides are small protein-like molecules used by neurons to communicate with each other. They influence a variety of brain functions, including pain perception, reward, food intake, metabolism, reproduction, social behaviors, and learning. In the context of hair and alopecia, neuropeptides can affect hair growth by modulating the activity of hair follicle cells and influencing the local immune response.

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research Modulation of Neuropeptide Y and Y1 Receptor Expression in the Amygdala by Fluctuations in the Brain Content of Neuroactive Steroids During Ethanol Drinking Discontinuation in Y1R/LacZ Transgenic Mice

15 citations , November 2007 in “Journal of Neurochemistry”

Stopping alcohol after long-term use causes anxiety and changes brain chemicals.

research Changes in Expression of the Neuropeptide Y Y1 Receptor Gene in the Medial Amygdala of Transgenic Mice During Pregnancy and After Delivery

12 citations , September 2002 in “Journal of Neurochemistry”

Pregnancy-related hormone changes affect Y1 receptor gene expression in mice.

research Increased Expression of the Gene for the Y1 Receptor of Neuropeptide Y in the Amygdala and Paraventricular Nucleus of Y1R/LacZ Transgenic Mice in Response to Restraint Stress

22 citations , April 2004 in “Journal of Neurochemistry”

Acute stress increases Y1 receptor gene expression in certain brain areas, but repeated stress does not.

Recent Advances in Neuropeptide-Related Omics and Gene Editing: Spotlight on NPY and Somatostatin and Their Roles in Growth and Food Intake of Fish

research Recent Advances in Neuropeptide-Related Omics and Gene Editing: Spotlight on NPY and Somatostatin and Their Roles in Growth and Food Intake of Fish

October 2022 in “Frontiers in Endocrinology”

New tools show that in fish, NPY increases feeding and somatostatin decreases it.

research Sequence-Structure Based Phylogeny of GPCR Class A Rhodopsin Receptors

57 citations , May 2014 in “Molecular Phylogenetics and Evolution”

The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 72 upvotes 1 year ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community He used Dutasteride for 20 years. Interview

in Treatment 114 upvotes 1 year ago

Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Creatine is the opposite of minoxidil !

in Research/Science 323 upvotes 1 month ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

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