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Glossary Neuropeptides

small protein-like molecules that neurons use to communicate

Neuropeptides are small protein-like molecules used by neurons to communicate with each other. They influence a variety of brain functions, including pain perception, reward, food intake, metabolism, reproduction, social behaviors, and learning. In the context of hair and alopecia, neuropeptides can affect hair growth by modulating the activity of hair follicle cells and influencing the local immune response.

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research Modulation of neuropeptide Y and Y₁ receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y₁R/LacZ transgenic mice

15 citations , November 2007 in “Journal of Neurochemistry”

In this study, ethanol discontinuation in Y 1 R / LacZ transgenic mice significantly decreased neuropeptide Y immunoreactivity and increased Y 1 receptor gene expression in the amygdala, with evidence suggesting an important role for the progesterone metabolite 3α,5α‐TH PROG in these changes.

research Changes in expression of the neuropeptide Y Y₁ receptor gene in the medial amygdala of transgenic mice during pregnancy and after delivery

12 citations , September 2002 in “Journal of Neurochemistry”

This study found that changes in the brain concentrations of neuroactive steroids during pregnancy are linked to increased Y 1 receptor gene expression in the medial amygdala of transgenic mice.

Restoring Neuropeptide Y Levels In The Hypothalamus Ameliorates Premature Aging Phenotype In Mice

research Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice

4 citations , February 2025 in “GeroScience”

This study found that restoring hypothalamic NPY levels in mice delayed aging-related characteristics such as fat loss, hair loss, and memory decline, suggesting that maintaining these levels could be important for counteracting aging and its effects.

Recent Advances in Neuropeptide-Related Omics and Gene Editing: Spotlight on NPY and Somatostatin and Their Roles in Growth and Food Intake of Fish

research Recent advances in neuropeptide-related omics and gene editing: Spotlight on NPY and somatostatin and their roles in growth and food intake of fish

October 2022 in “Frontiers in Endocrinology”

This review discusses recent advancements in omics and gene editing technologies for studying neuropeptides and receptors in fish, but reports no new experimental findings; the authors highlight the need for further research in this area.

research Neuropeptídeos na pele

27 citations , August 2003 in “Anais Brasileiros de Dermatologia”

This review discusses the roles of several neuropeptides in skin-immune interactions and inflammatory responses, reporting no new results and emphasizing the need for further study in conditions such as psoriasis and dermatitis.

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community He used Dutasteride for 20 years. Interview

113 upvotes 1 year ago

Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

community C’est terrible - at my wits end

in Female 450 upvotes 2 years ago

A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

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learn Pea peptides

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