Changes in Expression of the Neuropeptide Y Y1 Receptor Gene in the Medial Amygdala of Transgenic Mice During Pregnancy and After Delivery

September 2002 in “ Journal of Neurochemistry ”

Alessandra Oberto, Mariangela Serra, Maria Giuseppina Pisu, Giovanni Biggio, Carola Eva

neuropeptide Y Y1 receptor progesterone 5α-reductase inhibitor GABAergic system NPY–Y1 receptor neuroactive steroids finasteride Propecia

TLDR Pregnancy-related hormone changes affect Y1 receptor gene expression in mice.

The study investigated the effects of physiological fluctuations in neuroactive steroid concentrations during pregnancy on Y1 receptor gene expression in the medial amygdala of transgenic mice. It was found that cerebrocortical concentrations of progesterone and its metabolites increased on day 18 of pregnancy and returned to normal 2 days after delivery. Correspondingly, Y1 receptor gene expression also increased during pregnancy and normalized post-delivery. The administration of finasteride, a 5α-reductase inhibitor, prevented these increases, indicating that changes in neuroactive steroid levels during pregnancy were linked to alterations in Y1 receptor gene expression. This suggested a functional interaction between the GABAergic and NPY–Y1 receptor systems.

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research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

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community C’est terrible - at my wits end

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community He used Dutasteride for 20 years. Interview

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community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 1 year ago

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