Modulation of Neuropeptide Y and Y1 Receptor Expression in the Amygdala by Fluctuations in the Brain Content of Neuroactive Steroids During Ethanol Drinking Discontinuation in Y1R/LacZ Transgenic Mice

    November 2007 in “ Journal of Neurochemistry ”
    Carola Eva, Paolo Mele, Devis Collura … Giovanni Biggio
    Studysummary In this study, ethanol discontinuation in Y 1 R / LacZ transgenic mice significantly decreased neuropeptide Y immunoreactivity and increased Y 1 receptor gene expression in the amygdala, with evidence suggesting an important role for the progesterone metabolite 3α,5α‐TH PROG in these changes.
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    Research cited in this study 6

    1. Changes In Expression Of The Delta Subunit Of The GABA A Receptor And In Receptor Function Induced By Progesterone Exposure And Withdrawal Journal of Neurochemistry · 2006
    2. Social Isolation-Induced Increase in Alpha-4 and Delta Subunit Gene Expression Is Associated with Greater Efficacy of Ethanol on Steroidogenesis and GABA-A Receptor Function Journal of Neurochemistry · 2006
    3. Effects of Finasteride on Chronic and Acute Ethanol Withdrawal Severity in the WSP and WSR Selected Lines Alcoholism: Clinical and Experimental Research · 2005
    4. The Role of Pregnane Neurosteroids in Ethanol Withdrawal: Behavioral Genetic Approaches Pharmacology & Therapeutics · 2004
    5. Changes in Expression of the Neuropeptide Y Y1 Receptor Gene in the Medial Amygdala of Transgenic Mice During Pregnancy and After Delivery Journal of Neurochemistry · 2002
    6. Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997