Changes In Expression Of The Delta Subunit Of The GABA A Receptor And In Receptor Function Induced By Progesterone Exposure And Withdrawal

July 2006 in “ Journal of Neurochemistry ”

Maria Cristina Mostallino, Maria Luisa Mura, Elisabetta Maciocco, Luca Murru, Enrico Sanna, Giovanni Biggio

progesterone 3α,5α-THPROG GABAA receptor δ subunit 5α-reductase inhibitor finasteride GABA receptor Propecia

TLDR Progesterone affects GABAA receptor function by altering δ subunit levels.

The study investigated the effects of progesterone and its metabolite 3α,5α-THPROG on the δ subunit of GABAA receptors in cultured rat hippocampal neurons. It was found that 1 day of progesterone treatment increased δ subunit mRNA and protein levels, while 6 days of treatment decreased them. Withdrawal from progesterone led to an up-regulation of the δ subunit, peaking 9-12 hours after withdrawal. These changes were mirrored by alterations in GABAA receptor function and were blocked by the 5α-reductase inhibitor finasteride. The findings suggested that 3α,5α-THPROG plays a crucial role in modulating GABAergic synapses.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice

48 citations , February 1999 in “PubMed”

Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.

research Finasteride

187 citations , January 1994 in “The New England Journal of Medicine”

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Related Community Posts Join

6 / 179 results

community Completely defeated after trying so hard with topical finasteride.

in Finasteride/Dutasteride 24 upvotes 2 years ago

A user who has tried multiple treatments for hair loss, including oral and topical finasteride and liposomal finasteride, but experienced severe side effects in each case; the user is considering trying RU58841 or aromatise inhibitors as alternatives.

community 1.5 years of Fin, switch 3 months ago to Dut, with 5 moths of Min too

in Progress Pictures 104 upvotes 3 years ago

User switched from Fin to Dut for better hair loss results, using 0.5mg Dut and 1ml Min daily. Some discuss potential side effects and benefits of Dut compared to Fin.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 71 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community risks with finasteride and dutasteride

in Research/Science 141 upvotes 5 months ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

in Finasteride/Dutasteride 191 upvotes 3 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

Related Research

1 / 1 results

research Relating Neurosteroid Modulation of Inhibitory Neurotransmission to Behavior

18 citations , September 2021 in “Journal of Neuroendocrinology”

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.