Interleukin 6: Insights Into Its Function in Skin by Overexpression in Transgenic Mice

    June 1992 in “ Proceedings of the National Academy of Sciences ”
    Kursad Turksen, Thomas S. Kupper, Linda Degenstein … Elaine Fuchs
    Studysummary In this study, IL-6 expression in transgenic mice thickened the stratum corneum without causing increased epidermal proliferation or inflammation, suggesting it may enhance skin protection rather than directly induce inflammation.
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    Research cited in this study 2

    1. Transgenic Mice Provide New Insights Into the Role of TGF-Alpha During Epidermal Development and Differentiation Genes & Development · 1991
    2. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989

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