Tight Junctions Form a Barrier in Porcine Hair Follicles

    December 2015 in “ European journal of cell biology ”
    Christiane Mathes, Johanna M. Brandner, Michael Laue … Claus‐Michael Lehr
    Studysummary In this study, researchers demonstrated that follicular tight junctions in porcine skin form a barrier to nanoparticle penetration, particularly in upper regions, which supports its use as a model for human skin.
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    Research cited in this study 13

    1. Nanocarriers for Optimizing the Balance Between Interfollicular Permeation and Follicular Uptake of Topically Applied Clobetasol to Minimize Adverse Effects Journal of Controlled Release · 2015
    2. Inverse Micellar Sugar Glass (IMSG) Nanoparticles for Transfollicular Vaccination Journal of controlled release · 2015
    3. Immunolocalization of Junctional Proteins in Human Hairs Indicates That the Membrane Complex Stabilizes the Inner Root Sheath While Desmosomes Contact the Companion Layer Through Specific Keratins Acta Histochemica · 2013
    4. Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata Pharmaceutical Research · 2012
    5. Hair Follicle Targeting with Nanoparticles Springer eBooks · 2012
    6. An Atlas of Hair Pathology with Clinical Correlations CRC Press eBooks · 2012
    7. Neonatal Ichthyosis And Sclerosing Cholangitis Syndrome Journal of Pediatric Gastroenterology and Nutrition · 2011
    8. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    9. Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells by Hair Follicles and Their Transport in Mice ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    10. In Vitro Permeation of Drugs Into Porcine Hair Follicles: Is It Quantitatively Equivalent to Permeation Into Human Hair Follicles? Journal of Pharmacy and Pharmacology · 2008
    11. Imaging of Zinc Oxide Nanoparticle Penetration in Human Skin In Vitro and In Vivo Journal of biomedical optics · 2008
    12. Delayed Epidermal Permeability Barrier Formation and Hair Follicle Aberrations in Inv-Cldn6 Mice Mechanisms of development · 2005
    13. A Novel Epithelial Keratin, hK6irs1, Is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells of the Human Hair Follicle Journal of Investigative Dermatology · 2002