Tight Junctions Form a Barrier in Porcine Hair Follicles

December 2015 in “ European journal of cell biology ”

Christiane Mathes, Johanna M. Brandner, Michael Laue, Simon Sebastian Raesch, Steffi Hansen, Antonio Virgilio Failla, Sabine Vidal, Ingrid Moll, Ulrich F. Schaefer, Claus‐Michael Lehr

tight junctions Cldn-1 Cldn-4 Ocln ZO-1 infundibulum suprabulbar region outer root sheath Huxley's layer inner root sheath EDTA stratum corneum nanoparticles permeability hair follicles

TLDR Tight junctions create a barrier in pig hair follicles that controls what can enter the skin.

In this study, researchers investigated the presence and functionality of tight junctions (TJs) in porcine hair follicles (HFs). They found that TJs, specifically proteins Cldn-1, -4, Ocln, and ZO-1, were present from the infundibulum down to the suprabulbar region of the outer root sheath (ORS) and in Huxley's layer of the inner root sheath (IRS). These TJs formed a barrier that could be modulated using EDTA. The study also demonstrated that nanoparticles applied to the skin were mostly found in areas with both stratum corneum (SC) and TJ barriers, and less so in deeper regions where only TJs were present. This indicated that TJs play a significant role in regulating the permeability of substances in hair follicles.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

Nanocarriers for Optimizing the Balance Between Interfollicular Permeation and Follicular Uptake of Topically Applied Clobetasol to Minimize Adverse Effects

research Nanocarriers for Optimizing the Balance Between Interfollicular Permeation and Follicular Uptake of Topically Applied Clobetasol to Minimize Adverse Effects

69 citations, December 2015 in “Journal of Controlled Release”

Nanocapsules can improve clobetasol delivery to hair follicles, reducing side effects.

research Inverse Micellar Sugar Glass (IMSG) Nanoparticles for Transfollicular Vaccination

38 citations, May 2015 in “Journal of controlled release”

IMSG nanoparticles improve vaccine delivery and immune response through hair follicles.

Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata

research Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata

59 citations, October 2012 in “Pharmaceutical Research”

Squalene-based carriers improve delivery of a treatment to hair follicles for alopecia areata.

research Hair Follicle Targeting with Nanoparticles

5 citations, September 2012 in “Springer eBooks”

Nanoparticles can be used to deliver drugs to hair follicles, potentially improving treatments for conditions like acne and alopecia, and could also be used for vaccine delivery and gene therapy.

research An Atlas of Hair Pathology with Clinical Correlations

45 citations, May 2012 in “CRC Press eBooks”

The book helps doctors better understand and treat hair disorders due to gaps in their training.

research Selective Follicular Targeting by Modification of the Particle Sizes

263 citations, February 2011 in “Journal of Controlled Release”

Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.

research Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells by Hair Follicles and Their Transport in Mice

119 citations, December 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Nanoparticles can deliver vaccines through hair follicles, triggering immune responses and providing protection.

research Imaging of Zinc Oxide Nanoparticle Penetration in Human Skin In Vitro and In Vivo

264 citations, January 2008 in “Journal of biomedical optics”

Zinc oxide nanoparticles in sunscreen do not penetrate deep into the skin.

research Delayed Epidermal Permeability Barrier Formation and Hair Follicle Aberrations in Inv-Cldn6 Mice

63 citations, April 2005 in “Mechanisms of development”

Mice with too much Claudin-6 have skin barrier problems and abnormal hair growth.

research A Novel Epithelial Keratin, hK6irs1, Is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells of the Human Hair Follicle

86 citations, May 2002 in “Journal of Investigative Dermatology”

A new keratin, hK6irs1, is found in all layers of the hair follicle's inner root sheath.

Similar Research

5 / 1000+ results

The Role of Tight Junctions in Skin Barrier Function and Dermal Absorption

research The TFIID Subunit TAF4 Regulates Keratinocyte Proliferation and Has Cell-Autonomous and Non-Cell-Autonomous Tumor Suppressor Activity in Mouse Epidermis

28 citations, July 2007 in “Development”

TAF4 is important for skin cell growth and helps prevent skin cancer in mice.

Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

2 citations, August 2020 in “Scientific reports”

Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.

Tight Junctions Form a Barrier in Porcine Hair Follicles

Research cited in this study

research Nanocarriers for Optimizing the Balance Between Interfollicular Permeation and Follicular Uptake of Topically Applied Clobetasol to Minimize Adverse Effects

research Inverse Micellar Sugar Glass (IMSG) Nanoparticles for Transfollicular Vaccination

research Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata

research Hair Follicle Targeting with Nanoparticles

research An Atlas of Hair Pathology with Clinical Correlations

research Selective Follicular Targeting by Modification of the Particle Sizes

research Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells by Hair Follicles and Their Transport in Mice

research Imaging of Zinc Oxide Nanoparticle Penetration in Human Skin In Vitro and In Vivo

research Delayed Epidermal Permeability Barrier Formation and Hair Follicle Aberrations in Inv-Cldn6 Mice

research A Novel Epithelial Keratin, hK6irs1, Is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells of the Human Hair Follicle

Related Community Posts Join

community Could low blood flow to the head cause an increased rate of thinning?

community This community was super helpful to me a while ago, but it feels so good to be off finasteride

community hairloss in my 20s has ruined my life.

community If RU58841 is such an effective anti androgen

community What was your “f*ck I’m balding” story?

Similar Research

research The Role of Tight Junctions in Skin Barrier Function and Dermal Absorption

research Tight Junction Barriers in Human Hair Follicles – Role of Claudin-1

research Delayed Epidermal Permeability Barrier Formation and Hair Follicle Aberrations in Inv-Cldn6 Mice

research The TFIID Subunit TAF4 Regulates Keratinocyte Proliferation and Has Cell-Autonomous and Non-Cell-Autonomous Tumor Suppressor Activity in Mouse Epidermis

research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)