TLDR Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.
The study investigated the expression and activation of matriptase, a serine protease, in human hair follicles and sebaceous glands, finding it highly expressed in proliferative cells and activated in specific regions like the hair bulb and outer root sheath. Matriptase's role in cell proliferation and differentiation was highlighted, with its activity regulated by the inhibitor HAI-1. The matriptase-HGF-c-MET pathway was suggested to be crucial for hair follicle growth and function. Differences in matriptase expression between humans and rodents were noted, potentially explaining phenotypic differences in related conditions. The study concluded that matriptase is essential for early hair growth stages and maintaining the stem cell niche.
January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” Skin lesions in Carney complex are likely caused by a specific group of skin cells that promote pigment production due to a genetic mutation.
35 citations
,
January 2011 in “Journal of Biological Chemistry” sPLA2-X is crucial for normal hair growth and follicle health.
3 citations
,
May 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin lesions in Carney Complex are caused by a gene change in some skin cells that leads to increased pigmentation and may lead to tumors.
28 citations
,
December 2015 in “Journal of biological chemistry/The Journal of biological chemistry” Prostasin has two roles in skin: one for normal skin development without needing activation, and another for proper hair growth that requires activation.
9 citations
,
March 2018 in “European journal of dermatology/EJD. European journal of dermatology” A new mutation in the ST14 gene causes a rare skin and hair disorder in a specific family.
