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GlossaryMatriptase

enzyme crucial for skin barrier function and hair growth

Matriptase is an enzyme that plays a crucial role in the development and maintenance of skin and hair. It is involved in the activation of other proteins that are essential for skin barrier function and hair growth. Dysregulation of matriptase activity has been linked to various skin disorders and conditions like alopecia.

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research Matriptase/MT-SP1 Is Required for Postnatal Survival, Epidermal Barrier Function, Hair Follicle Development, and Thymic Homeostasis

324 citations , May 2002 in “Oncogene”

research Matriptase: Potent Proteolysis on the Cell Surface

165 citations , January 2006 in “Molecular Medicine”

Matriptase is crucial for skin, hair, and immune cell health, and its imbalance can lead to cancer.

research Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway

137 citations , October 2009 in “The American journal of pathology”

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

research Autosomal Ichthyosis With Hypotrichosis Syndrome Displays Low Matriptase Proteolytic Activity and Is Phenocopied in ST14 Hypomorphic Mice

101 citations , October 2007 in “Journal of Biological Chemistry”

Reduced matriptase activity causes skin and hair issues in both humans and mice.

research Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis

100 citations , May 2006 in “American Journal Of Pathology”

Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.

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