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GlossaryMatriptase

enzyme crucial for skin barrier function and hair growth

Matriptase is an enzyme that plays a crucial role in the development and maintenance of skin and hair. It is involved in the activation of other proteins that are essential for skin barrier function and hair growth. Dysregulation of matriptase activity has been linked to various skin disorders and conditions like alopecia.

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research Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin

28 citations , December 2015 in “Journal of biological chemistry/The Journal of biological chemistry”

Prostasin has two roles in skin: one for normal skin development without needing activation, and another for proper hair growth that requires activation.

research Autosomal Ichthyosis With Hypotrichosis Syndrome Displays Low Matriptase Proteolytic Activity and Is Phenocopied in ST14 Hypomorphic Mice

101 citations , October 2007 in “Journal of Biological Chemistry”

Reduced matriptase activity causes skin and hair issues in both humans and mice.

research Matriptase Expression and Zymogen Activation in Human Pilosebaceous Unit

9 citations , September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.

research Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway

137 citations , October 2009 in “The American journal of pathology”

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Matriptase Activation and Shedding with HAI-1 Induced by Steroid Sex Hormones in Human Prostate Cancer Cells, but Not in Breast Cancer Cells

research Matriptase Activation and Shedding with HAI-1 Induced by Steroid Sex Hormones in Human Prostate Cancer Cells, but Not in Breast Cancer Cells

56 citations , February 2006 in “American journal of physiology. Cell physiology”

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

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