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    Glossary Matriptase

    enzyme crucial for skin barrier function and hair growth

    Matriptase is an enzyme that plays a crucial role in the development and maintenance of skin and hair. It is involved in the activation of other proteins that are essential for skin barrier function and hair growth. Dysregulation of matriptase activity has been linked to various skin disorders and conditions like alopecia.

    Research 10 of 56

    1. Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis Oncogene · 2002 · 324 citations
    2. Matriptase: Potent Proteolysis on the Cell Surface Molecular Medicine · 2006 · 165 citations
    3. Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway ˜The œAmerican journal of pathology · 2009 · 137 citations
    4. Autosomal Ichthyosis with Hypotrichosis Syndrome Displays Low Matriptase Proteolytic Activity and Is Phenocopied in ST14 Hypomorphic Mice Journal of Biological Chemistry · 2007 · 101 citations
    5. Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis American Journal Of Pathology · 2006 · 100 citations
    6. Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells American journal of physiology. Cell physiology · 2006 · 56 citations
    7. Matrix-Degrading Type II Transmembrane Serine Protease Matriptase: Its Role in Cancer Development and Malignancy 2006 · 12 citations
    8. Matriptase Expression and Zymogen Activation in Human Pilosebaceous Unit 2013 · 9 citations
    9. Matriptase-2, A Novel Suppressor of Hepcidin. Blood · 2009
    10. Ichthyosis, Follicular Atrophoderma, and Hypotrichosis Caused by Mutations in ST14 Is Associated with Impaired Profilaggrin Processing Journal of Investigative Dermatology · 2008 · 99 citations
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