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Matriptase Activation and Shedding with HAI-1 Induced by Steroid Sex Hormones in Human Prostate Cancer Cells, but Not in Breast Cancer Cells

research Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells

56 citations , February 2006 in “American journal of physiology. Cell physiology”

This study observed that in hormone-starved prostate cancer cells, the androgen 5alpha-dihydrotestosterone rapidly induces matriptase activation and shedding, which involves androgen receptor signaling and requires both transcription and protein synthesis.

research Matriptase: Potent Proteolysis on the Cell Surface

165 citations , January 2006 in “Molecular Medicine”

This review highlights the role of matriptase in epithelial differentiation and cancer, noting that unregulated matriptase expression can enhance cancer progression in animal models, but reports no new experimental data.

research Matrix-Degrading Type II Transmembrane Serine Protease Matriptase: Its Role in Cancer Development and Malignancy

12 citations , October 2006

This review discusses the role of matriptase and its inhibitor HAI-1 in epithelial homeostasis and cancer development, highlighting their imbalance's link to cancer progression without presenting new experimental results.

research Matriptase Expression and Zymogen Activation in Human Pilosebaceous Unit

9 citations , September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

In this study, researchers found that the matriptase-HGF-c-MET pathway may be activated in proliferative cells of human hair follicles and sebaceous glands, suggesting a potential role in hair growth regulation.

research Ichthyosis and Trichothiodystrophy: the Tay and PIBI(D)S Syndromes

2 citations , January 1989

This article discusses the history and understanding of Tay syndrome, recognizing it as a distinct condition related to ichthyotic erythroderma, mental retardation, and brittle hair but reports no new clinical results.

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Learn

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learn Hair Transplant

Is a hair transplant safe? Hair transplants are generally safe when done by qualified professionals in sterile conditions.
Is a hair transplant painful? A hair transplant is generally comfortable due to local anesthesia, with mild post-procedure soreness possible.
Who is a good candidate for a hair transplant? Good candidates for hair transplants have sufficient donor hair and stable hair loss patterns.
All 4 questions on Hair Transplant →

learn sh-Polypeptide-7

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Community Join

5 / 62 results

community One year on oral fin and 7 months on oral min at 17 years old

in Progress Pictures 18 upvotes 5 months ago

A 17-year-old started using 1mg oral finasteride in April 2025 and increased oral minoxidil from 1.25mg to 2.5mg by December 2025. Users discuss progress, initial shedding, and suggest checking vitamin and mineral levels.

community 23male 10month finasteride and minoxidil

in Progress Pictures 481 upvotes 1 year ago

A 23-year-old male experienced good hair growth and increased self-confidence after 10 months of using oral finasteride (1.25mg) and topical minoxidil (5% twice a day), despite no decrease in hair shedding. He also used 1mm microneedling monthly and reported minor side effects like forgetfulness.

community My 11 month progress. I make a year in August.

400 upvotes 1 year ago

The user shared their 11-month hair loss treatment experience using Dutasteride daily and Minoxidil initially, noting improvements in hair density and texture. They stopped Minoxidil in February, observed no significant shedding, and plan to continue with Dutasteride, considering reintroducing Minoxidil for more regrowth.

community 1 mg Finasteride with 0.1% Topical Minoxidil

103 upvotes 2 weeks ago

A 27-year-old Indian user reports positive results with no side effects from using 5% Minoxidil with 0.1% Finasteride topically and taking 1mg Finasteride orally daily for hair loss. The user regrets not starting the treatment earlier and notes the appearance of baby hairs along the front hairline.

community 1 month after switching to topical Dut

in Is this regrowth? 216 upvotes 2 months ago

The user switched from topical finasteride/minoxidil to topical dutasteride/minoxidil, reporting thicker hair after one month. They used Happy Head products with 0.3% dutasteride and 8% minoxidil.

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