Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin

    December 2015 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Stine Friis, Daniel H. Madsen, Thomas H. Bugge
    Studysummary This study found that prostasin's proteolytic activity is necessary for normal hair follicle development in mice, but not for interfollicular epidermal development.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jbc.org →
    Discuss this study in the Community →

    Research cited in this study 3

    1. The CAP1/Prss8 Catalytic Triad Is Not Involved in PAR2 Activation and Protease Nexin-1 (PN-1) Inhibition The FASEB Journal · 2014
    2. Autosomal Ichthyosis With Hypotrichosis Syndrome Displays Low Matriptase Proteolytic Activity and Is Phenocopied in ST14 Hypomorphic Mice Journal of Biological Chemistry · 2007
    3. Matriptase/MT-SP1 Is Required for Postnatal Survival, Epidermal Barrier Function, Hair Follicle Development, and Thymic Homeostasis Oncogene · 2002