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    Glossary RSPO1

    protein regulating hair growth and skin development

    RSPO1, or R-spondin 1, is a protein that plays a crucial role in the regulation of hair growth and skin development. It activates the Wnt signaling pathway, which is essential for the proliferation and differentiation of hair follicle cells. Mutations in the RSPO1 gene can lead to conditions like palmoplantar hyperkeratosis and predispose individuals to certain types of alopecia.

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    Research 10 of 152

    1. RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development Orphanet journal of rare diseases · 2022 · 5 citations
    2. RSPO1, a potent inducer of pancreatic β cell neogenesis Cell Reports Medicine · 2025 · 1 citations
    3. H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development Epigenetics & Chromatin · 2025 · 1 citations
    4. Management of a Refractory EIF3E-RSPO2 Fusion Positive Pilomatrical Cancer Patient with Encyclopedic Tumor Analysis Guided Treatment Acta Scientific Cancer Biology · 2020
    5. The role of R-spondins and their receptors in bone metabolism Progress in Biophysics & Molecular Biology · 2016 · 25 citations
    6. Synchronous profiling and analysis of mRNAs and ncRNAs in the dermal papilla cells from cashmere goats BMC genomics · 2019 · 17 citations
    7. Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells Frontiers in Cell and Developmental Biology · 2020 · 8 citations
    8. Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway Acta Biochimica et Biophysica Sinica · 2023 · 8 citations
    9. Effects of watercress extract fraction on R‐spondin 1‐mediated growth of human hair International Journal of Cosmetic Science · 2022 · 4 citations
    10. Interpretation of the Yak Skin Single-Cell Transcriptome Landscape Animals · 2023
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