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    Glossary RSPO4

    protein involved in hair follicle development and regeneration

    RSPO4 stands for R-spondin 4, a protein that plays a crucial role in the Wnt signaling pathway, which is important for cell growth and development. In the context of hair biology, RSPO4 is involved in the regulation of hair follicle development and regeneration. Mutations in the RSPO4 gene can lead to conditions like anonychia, where individuals are born without fingernails or toenails.

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    Research 10 of 138

    1. RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development Orphanet journal of rare diseases · 2022 · 5 citations
    2. H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development Epigenetics & Chromatin · 2025 · 1 citations
    3. RSPO1, a potent inducer of pancreatic β cell neogenesis Cell Reports Medicine · 2025 · 1 citations
    4. Management of a Refractory EIF3E-RSPO2 Fusion Positive Pilomatrical Cancer Patient with Encyclopedic Tumor Analysis Guided Treatment Acta Scientific Cancer Biology · 2020
    5. Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells Frontiers in Cell and Developmental Biology · 2020 · 8 citations
    6. High-throughput screening of small molecule Wnt/β-catenin activators for hair and nail growth Communications Biology · 2026
    7. High-Throughput Screening for Discovering Small Molecules Capable of Increasing the Wnt/β-Catenin Signaling Pathway to Promote Hair and Nail Growth Research Square (Research Square) · 2024
    8. 189 Integrating single-cell and spatial transcriptomics of human hair follicles to define transcriptional signature of follicular dermal papilla 2022
    9. Genetic Mapping Of Hereditary Ectodermal Dysplasias And Hair Loss Genes 2011
    10. The role of R-spondins and their receptors in bone metabolism Progress in Biophysics & Molecular Biology · 2016 · 25 citations
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