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GlossaryRSPO4

protein involved in hair follicle development and regeneration

RSPO4 stands for R-spondin 4, a protein that plays a crucial role in the Wnt signaling pathway, which is important for cell growth and development. In the context of hair biology, RSPO4 is involved in the regulation of hair follicle development and regeneration. Mutations in the RSPO4 gene can lead to conditions like anonychia, where individuals are born without fingernails or toenails.

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High-Throughput Screening for Discovering Small Molecules Capable of Increasing the Wnt/β-Catenin Signaling Pathway to Promote Hair and Nail Growth

research High-Throughput Screening for Discovering Small Molecules Capable of Increasing the Wnt/β-Catenin Signaling Pathway to Promote Hair and Nail Growth

June 2024 in “Research Square (Research Square)”

Aminoacridine and Minoxidil together show promise for better hair and nail growth.

Integrating Single-Cell and Spatial Transcriptomics of Human Hair Follicles to Define Transcriptional Signature of Follicular Dermal Papilla

research Integrating Single-Cell and Spatial Transcriptomics of Human Hair Follicles to Define Transcriptional Signature of Follicular Dermal Papilla

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

The research identified specific genes that are active in the cells crucial for hair growth.

research Genetic Mapping of Hereditary Ectodermal Dysplasias and Hair Loss Genes

January 2011

Genetic mutations linked to ectodermal dysplasias and hair loss were identified in Pakistani families.

research The Localization of Label-Retaining Cells in Mouse Nails

22 citations , October 2007 in “Journal of Investigative Dermatology”

Stem cells in mouse nails are found in the nail matrix and may control nail growth.

research The Role of R-Spondins and Their Receptors in Bone Metabolism

25 citations , May 2016 in “Progress in Biophysics & Molecular Biology”

R-spondins and their receptors help increase bone growth and may be used to treat bone loss diseases.

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