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GlossaryRSPO4

protein involved in hair follicle development and regeneration

RSPO4 stands for R-spondin 4, a protein that plays a crucial role in the Wnt signaling pathway, which is important for cell growth and development. In the context of hair biology, RSPO4 is involved in the regulation of hair follicle development and regeneration. Mutations in the RSPO4 gene can lead to conditions like anonychia, where individuals are born without fingernails or toenails.

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High-Throughput Screening for Discovering Small Molecules Capable of Increasing the Wnt/β-Catenin Signaling Pathway to Promote Hair and Nail Growth

research High-Throughput Screening for Discovering Small Molecules Capable of Increasing the Wnt/β-Catenin Signaling Pathway to Promote Hair and Nail Growth

June 2024 in “Research Square (Research Square)”

Aminoacridine and Minoxidil together show promise for better hair and nail growth.

Integrating Single-Cell and Spatial Transcriptomics of Human Hair Follicles to Define Transcriptional Signature of Follicular Dermal Papilla

research Integrating Single-Cell and Spatial Transcriptomics of Human Hair Follicles to Define Transcriptional Signature of Follicular Dermal Papilla

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

The research identified specific genes that are active in the cells crucial for hair growth.

research The Role of R-Spondins and Their Receptors in Bone Metabolism

25 citations, May 2016 in “Progress in Biophysics & Molecular Biology”

R-spondins and their receptors help increase bone growth and may be used to treat bone loss diseases.

research Dental Cell Type Atlas Reveals Stem and Differentiated Cell Types in Mouse and Human Teeth

116 citations, September 2020 in “Nature Communications”

The research identified various cell types in mouse and human teeth, which could help in developing dental regenerative treatments.

research Variant PADI3 in Central Centrifugal Cicatricial Alopecia

95 citations, February 2019 in “The New England Journal of Medicine”

Mutations in the PADI3 gene are linked to a higher risk of scarring hair loss in women of African descent.

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