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    Glossary RSPO4

    protein involved in hair follicle development and regeneration

    RSPO4 stands for R-spondin 4, a protein that plays a crucial role in the Wnt signaling pathway, which is important for cell growth and development. In the context of hair biology, RSPO4 is involved in the regulation of hair follicle development and regeneration. Mutations in the RSPO4 gene can lead to conditions like anonychia, where individuals are born without fingernails or toenails.

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    Research 30 of 138

    1. RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development Orphanet journal of rare diseases · 2022 · 5 citations
    2. H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development Epigenetics & Chromatin · 2025 · 1 citations
    3. RSPO1, a potent inducer of pancreatic β cell neogenesis Cell Reports Medicine · 2025 · 1 citations
    4. Management of a Refractory EIF3E-RSPO2 Fusion Positive Pilomatrical Cancer Patient with Encyclopedic Tumor Analysis Guided Treatment Acta Scientific Cancer Biology · 2020
    5. Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells Frontiers in Cell and Developmental Biology · 2020 · 8 citations
    6. High-throughput screening of small molecule Wnt/β-catenin activators for hair and nail growth Communications Biology · 2026
    7. High-Throughput Screening for Discovering Small Molecules Capable of Increasing the Wnt/β-Catenin Signaling Pathway to Promote Hair and Nail Growth Research Square (Research Square) · 2024
    8. 189 Integrating single-cell and spatial transcriptomics of human hair follicles to define transcriptional signature of follicular dermal papilla 2022
    9. Genetic Mapping Of Hereditary Ectodermal Dysplasias And Hair Loss Genes 2011
    10. The role of R-spondins and their receptors in bone metabolism Progress in Biophysics & Molecular Biology · 2016 · 25 citations
    11. Synchronous profiling and analysis of mRNAs and ncRNAs in the dermal papilla cells from cashmere goats BMC genomics · 2019 · 17 citations
    12. The overexpression of R-spondin 3 affects hair morphogenesis and hair development along with the formation and maturation of the hair follicle stem cells Frontiers in Physiology · 2024 · 6 citations
    13. Effects of watercress extract fraction on R‐spondin 1‐mediated growth of human hair International Journal of Cosmetic Science · 2022 · 4 citations
    14. Interpretation of the Yak Skin Single-Cell Transcriptome Landscape Animals · 2023
    15. Sensitive Quantitative In Vivo Assay for Evaluating the Effects of Biomolecules on Hair Growth and Coloring Using Direct Microinjections into Mouse Whisker Follicles Biomolecules · 2023
    16. ISID1420 - Ashwagandha-derived exosome-like nanoparticles promote human hair growth ex vivo 2023
    17. 1420 Ashwagandha-derived exosome-like nanoparticles promote human hair growth ex vivo Journal of Investigative Dermatology · 2023
    18. Characterizing the cellular diversity and molecular signatures within the hair follicle dermal stem cell lineage PRISM (University of Calgary) · 2017
    19. Clinical Snippets Experimental Dermatology · 2016
    20. Clinical Snippets Journal of Investigative Dermatology · 2016
    21. Investigating the mechanisms underlying age-related dysfunctions in skin and hair follicle regeneration 2020
    22. Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway Acta Biochimica et Biophysica Sinica · 2023 · 8 citations
    23. The Localization of Label-Retaining Cells in Mouse Nails Journal of Investigative Dermatology · 2007 · 22 citations
    24. The developmental basis of fingerprint pattern formation and variation Cell · 2023 · 44 citations
    25. Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure Scientific Reports · 2016 · 48 citations
    26. Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells Molecules · 2020 · 5 citations
    27. Hox in the Niche Controls Hairy-geneity Cell Stem Cell · 2018 · 4 citations
    28. Variant <i>PADI3</i> in Central Centrifugal Cicatricial Alopecia The New England Journal of Medicine · 2019 · 95 citations
    29. Wnt signaling: the good and the bad Acta Biochimica et Biophysica Sinica · 2008 · 48 citations
    30. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Cell Stem Cell · 2018 · 43 citations