Mesenchyme Governs Hair Follicle Induction

    O. Mäkelä, Marja L. Mikkola
    Image of study
    TLDR The mesenchyme can start hair growth, but the exact signal that causes this is still unknown.
    The study investigates the role of mesenchyme in hair follicle development, revealing that the mesenchyme from the back skin of mouse embryos can induce hair follicle formation even before the formation of the dermal condensate, which is a precursor to the dermal papilla. The research demonstrates that unpatterned mesenchyme can initiate hair follicle development in oral epithelium, suggesting its inductive potential is not limited to pre-patterned skin regions. The study also examines the effects of Wnt signalling and Bmp activity inhibition on hair follicle induction. It finds that while the Wnt agonist R-spondin-1 triggers early placode-specific transcriptional responses, neither R-spondin-1 alone nor in combination with a Bmp receptor inhibitor is sufficient to induce hair follicle formation. This indicates that other factors are involved in the induction process, and the exact hair follicle-inducing signal remains unidentified.
    Discuss this study in the Community →

    Research cited in this study

    16 / 16 results

    Related Community Posts Join

    6 / 13 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  44 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Comprehensive Microneedling Guide

      in Microneedling  295 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Lavdik Hair Growth Serum?

      in Product 4 years ago
      A user is concerned about the legitimacy of a hair growth serum called Lavdik, which they ordered after seeing an ad for Jemros. The product contains ginger extract, ginseng extract, fleece flower root, grape seed oil, glycerol, carbomer, propylene glycol, and rosemary oil, and the user is unsure if it is effective or a scam.

    Related Research

    1 / 1 results