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    Mesenchyme Governs Hair Follicle Induction

    July 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    O. Mäkelä, Marja L. Mikkola

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that back skin mesenchyme from mouse embryos can induce hair follicle formation even before dermal condensate formation, but R-spondin-1 alone or with a Bmp receptor inhibitor was not sufficient for hair follicle induction.
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    Research cited in this study 21

    1. Molecular and Spatial Design of Early Skin Development bioRxiv (Cold Spring Harbor Laboratory) · 2022
    2. Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis The EMBO Journal · 2021
    3. Feather Arrays Are Patterned by Interacting Signaling and Cell Density Waves PLoS Biology · 2019
    4. Hierarchical Patterning Modes Orchestrate Hair Follicle Morphogenesis PLoS Biology · 2017
    5. LHX2 Is a Direct NF-κB Target Gene That Promotes Primary Hair Follicle Placode Down-Growth Development · 2016
    6. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    7. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    8. Early Inductive Events in Ectodermal Appendage Morphogenesis Seminars in cell & developmental biology · 2014
    9. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    10. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    11. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    12. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    13. Epidermal Patterning and Induction of Different Hair Types During Mouse Embryonic Development Birth defects research · 2009
    14. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    15. Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate Development · 2008
    16. Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes Developmental biology · 2008
    17. The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis Developmental biology · 2007
    18. Exploiting the Keratin 17 Gene Promoter to Visualize Live Cells in Epithelial Appendages of Mice Molecular and Cellular Biology · 2005
    19. Morpho-Regulation of Ectodermal Organs ˜The œAmerican journal of pathology · 2004
    20. Cellular and Extracellular Involvement in the Regeneration of the Rat Lower Vibrissa Follicle Development · 1992
    21. The Secret Life of the Hair Follicle Trends in genetics · 1992

    Related research 1

    1. Interrogating the Integument: The Role of the Epidermis in Hair Induction Experimental dermatology · 2014