High-Throughput Screening for Discovering Small Molecules Capable of Increasing the Wnt/β-Catenin Signaling Pathway to Promote Hair and Nail Growth

    June 2024 in “ Research Square (Research Square) ”
    Dong‐Youn Lee, Gulimila Abudureyimu, Hyung‐Suk Jang … Minjeong Kang

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary In this study, researchers identified nine FDA-approved drugs that activate the Wnt signaling pathway, with Aminoacridine, especially when combined with Minoxidil, showing promising effects on hair and nail growth in mice, suggesting potential treatments for hair and nail loss pending further clinical trials.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 19

    1. Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2022
    2. Inhibition of Class I HDACs Preserves Hair Follicle Inductivity in Postnatal Dermal Cells Scientific Reports · 2021
    3. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    4. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-Blind Controlled Study Journal of Pharmacy and Pharmaceutical Sciences · 2021
    5. Design of In Vitro Hair Follicles for Different Applications in the Treatment of Alopecia: A Review Biomedicines · 2021
    6. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    7. Two-Cell Assemblage Assay: A Simple In Vitro Method for Screening Hair Growth-Promoting Compounds Frontiers in Cell and Developmental Biology · 2020
    8. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    9. Glucose Metabolism Regulates Expression of Hair-Inductive Genes of Dermal Papilla Spheres via Histone Acetylation Scientific reports · 2020
    10. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    11. Medicinal Plants for the Treatment of Hair Loss and the Suggested Mechanisms Current Pharmaceutical Design · 2018
    12. Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid Stem cells international · 2017
    13. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    14. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    15. TSH Is a Novel Neuroendocrine Regulator of Selected Keratins in the Human Hair Follicle Journal of Dermatological Science · 2011
    16. Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin ˜The œAmerican journal of pathology · 2009
    17. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    18. Keratins of the Human Hair Follicle International review of cytology · 2005
    19. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005

    Related research 1

    1. Temporal-Spatial Activation of Wnt-Signaling Within Type 1 and Type 2 Immunity During Wound Healing Journal of Investigative Dermatology · 2019