TSH Is a Novel Neuroendocrine Regulator of Selected Keratins in the Human Hair Follicle

June 2011 in “ Journal of Dermatological Science ”

Yuval Ramot, Guoyou Zhang, Tamás Bı́ró, Erika Lisztes, Wolfang Funk, Arieh Ingber, Lutz Langbein, Ralf Paus

thyroid-stimulating hormone TSH keratin human hair follicles prolactin PRL thyrotropin-releasing hormone TRH neuroendocrine regulation

TLDR TSH influences keratin expression in human hair follicles.

The study explored the role of thyroid-stimulating hormone (TSH) as a neuroendocrine regulator of keratin expression in human hair follicles (HFs). It was found that TSH, along with other hormones like prolactin (PRL) and thyrotropin-releasing hormone (TRH), significantly influenced the expression of selected keratins in HF organ cultures. Despite TSH's role in regulating keratin expression, its overall functions in HF biology were not fully understood. The research highlighted the complex neuroendocrine regulation of keratin expression, suggesting potential pathways for influencing hair growth and follicle function.

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Research cited in this study

14 / 14 results

research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation

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Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ

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Hormones control keratin production in skin and hair.

research Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation

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Msx2 and Foxn1 are both crucial for hair growth and health.

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Thyroid-stimulating hormone affects hair follicles but doesn't change hair growth or color.

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research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

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research The Human Keratins: Biology And Pathology

1398 citations , May 2008 in “Histochemistry and Cell Biology”

Keratins are crucial for cell stability, wound healing, and cancer diagnosis.

research Keratins of the Human Hair Follicle

276 citations , January 2005 in “International review of cytology”

More research is needed to understand how hair keratins work and their role in hair disorders.

research Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation

158 citations , December 2002 in “Development”

Msx2-deficient mice experience irregular hair growth and loss due to disrupted hair cycle phases.

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TSH Is a Novel Neuroendocrine Regulator of Selected Keratins in the Human Hair Follicle

Research cited in this study

research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation

research Morphogenesis and Maintenance of the 3D Thymic Medulla and Prevention of Nude Skin Phenotype Require FoxN1 in Pre- and Post-Natal K14 Epithelium

research Thyroid-Stimulating Hormone: A Novel, Locally Produced Modulator of Human Epidermal Functions, Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones

research Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ

research Exploring the Thyroid-Skin Connection: Concepts, Questions, and Clinical Relevance

research Thyrotropin Releasing Hormone: A New Player in Human Hair Growth Control

research The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice

research Endocrine Controls of Keratin Expression

research Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation

research Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research The Human Keratins: Biology And Pathology

research Keratins of the Human Hair Follicle

research Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation

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