Inhibition of Class I HDACs Preserves Hair Follicle Inductivity in Postnatal Dermal Cells

December 2021 in “ Scientific Reports ”

Minji Park, Sunhyae Jang, Jin Ho Chung, Oh Sang Kwon, Seong Jin Jo

class I HDACs MS-275 hair follicle inductivity postnatal dermal cells histone H3 acetylation BMP4 HEY1 WIF1 Wnt signaling pathway alopecia histone deacetylases hair follicles dermal cells bone morphogenetic protein 4 Wnt pathway

Studysummary This study found that inhibiting class I histone deacetylases in postnatal mouse dermal cells preserved their ability to induce hair follicles during culture by increasing specific gene expressions and activating the Wnt signaling pathway. Our plain-language summary of this paper — not a Tressless recommendation.

This study demonstrates that inhibiting class I histone deacetylases (HDACs) with MS-275 preserves hair follicle (HF) inductivity in postnatal dermal cells (DCs) during culture. Normally, DCs lose HF inductivity rapidly in vitro, but MS-275 maintains this ability by increasing histone H3 acetylation, which in turn upregulates HF inductive genes like BMP4, HEY1, and WIF1, and activates the Wnt signaling pathway. These findings suggest that targeting class I HDACs could be a promising strategy for inducing new HFs, offering potential therapeutic benefits for treating alopecia.

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